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MetabolomicsIntegrated Exposomics/Metabolomics for Rapid Exposure and Effect Analyses

The totality of environmental exposures and lifestyle factors, commonly referred to as the exposome, are poorly understood. Measuring the myriad of chemicals that humans are exposed to is immensely challenging and identifying disrupted metabolic pathways is even more complex. Here, we present a n...

2023-10-26 | MTBLS4556 | MetaboLights
UnknownAPOE ε4 carriers may undergo synaptic damage conferring risk of Alzheimer's disease.
Not available
S-EPMC5742562 | biostudies-literature
ProteomicsProfiling of Bacillus thuringiensis biopesticides: A high-resolution LC-MS/MS approach for subspecies identification and protein quantification
The widespread use of Bacillus thuringiensis (Bt)- based biopesticides in organic farming presents challenges for food diagnostics due to the genetic similarity between Bt and the pathogenic Bacillus cereus as well as the lack of data on the insecticidal protein concentrations in treated food sample...
ORGANISM(S): Bacillus Thuringiensis Serovar Kurstaki Bacillus Thuringiensis Bacillus Thuringiensis Serovar Aizawai Bacillus Thuringiensis Serovar Israelensis 
PXD071216 | panorama
ProteomicsProteomic profiling reveals CDK6 upregulation as a targetable resistance mechanism for lenalidomide in multiple myeloma
The immunomodulatory drugs (IMiDs) lenalidomide and pomalidomide are highly effective treatments for multiple myeloma. However, virtually all patients eventually relapse due to acquired drug resistance with resistance-causing genetic alterations being found only in a small subset of cases. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD021265 | Pride
Multiple myeloma Tmt Lc-ms Cdk6 
GenomicsCIITA
Creation of comprehensive CIITA and RFX5 ChIP-Seq profiles in primary B cells and monocytes
ORGANISM(S): Homo sapiens 
2014-10-08 | E-MTAB-2424 | biostudies-arrayexpress
TranscriptomicsTime kinetics of gene expression in NK92 cells after Plasmodium falciparum-iRBC encounter
To study the effect of Plasmodium falciparum-infected erythrocytes on gene expression in NK92 cells, microarray analysis after 6, 12 and 24 hours of co-culture with either uRBC or iRBC was performed. The aim was to identify pathways in NK92 cells that are switched on after iRBC encounter in a time-d...
ORGANISM(S): Homo sapiens 
2011-11-12 | E-GEOD-26876 | biostudies-arrayexpress
TranscriptomicsHuman Monocytes to M-CSF differentiated Macrophages
This dataset was created to study M-CSF dependent in vitro differentiation of human monocytes to macrophages as a model process to demonstrate that independent component analysis (ICA) is a useful tool to support and extend knowledge-based strategies and to identify complex regulatory networks or no...
ORGANISM(S): Homo sapiens 
2011-11-07 | E-GEOD-9801 | biostudies-arrayexpress
ProteomicsSynergistic efficacy of combined SUMOylation and proteasome inhibition in multiple myeloma
Relapsed/refractory multiple myeloma (r/r MM) is a disease with often poor prognosis. Hyperactive SUMO signaling is involved in both cancer pathogenesis and cancer progression. A state of increased SUMOylation has been associated with aggressive cancer biology. Here, we found that r/r MM is characte...
ORGANISM(S): Homo sapiens (Human) 
2022-08-01 | PXD032316 | Pride
Proteasome inhibitor Myeloma Sumoylation inhibitor 
ProteomicsProteogenomic landscape of multiple myeloma
Multiple myeloma is a plasma cell malignancy of the bone marrow. Despite therapeutic advances, multiple myeloma remains incurable and better risk stratification as well as new therapies are therefore highly needed. The proteome of multiple myeloma has not been systematically assessed before and hold...
ORGANISM(S): Homo sapiens (Human) 
2024-07-09 | PXD038437 | Pride
Multiple myeloma Proteogenomics Plasma cells Therapeutic targets Clinical proteomics Risk signatures Biomarkers 
TranscriptomicsGene expression profiling of Plasmodium falciparum after co-culture with NK cells
The aim of the study was to determine the effect of natural killer (NK) cells on the global gene expression in Plasmodium falciparum. FCR3-CSA-infected red blood cells (RBCs) were co-cultured for 24h with NK92. Prior to RNA extraction, the parasitized RBCs were separated via Ficoll from the lymphocy...
ORGANISM(S): Plasmodium falciparum 
2012-06-30 | E-GEOD-19010 | biostudies-arrayexpress
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