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MetabolomicsBacterial profiles analysed by REIMS using Xevo G2-XS

Rapid evaporative ionisation mass spectrometry (REIMS) has been demonstrated capable of bacterial speciation by differentiation of their metabolic/lipidomic profiles. Previous work has shown the use of hand-held probes [1,2], and this dataset makes use of a robotic sampling probe which allows for...

2025-07-11 | MTBLS11776 | MetaboLights
GenomicsG-Quadruplex structures are stable and detectable in human genomic DNA.
The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome. Herein, we address the hypothesis that G-quadruplex structures can exist within double-stranded genomic DNA using a G-quadruplex-specific probe. An engineered antibody is ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-45241 | biostudies-arrayexpress
TranscriptomicsBone marrows infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins.
In neuroblastoma (NB) patients metastasis are the main cause of death, thus understanding the biological and genetic features of the metastatic NB cells is needed to reach efficient target-based therapies for high risk patients. In recent years, several prognostic signatures derived from gene expres...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-25623 | biostudies-arrayexpress
TranscriptomicsTumor-Derived G-CSF Facilitates Neoplastic Growth through a Granulocytic Myeloid-Derived Suppressor Cell-Dependent Mechanism
Global gene expression studies were performed to determine whether the granulocytic-like MDSC populations from G-CSF treated mice resembled those of tumor-bearing (TB) mice more so than those of the non-tumor-bearing control (i.e., WT) at a molecular level. Splenic CD11b+Gr-1high cell populations fr...
ORGANISM(S): Mus musculus 
2011-12-07 | E-GEOD-32209 | biostudies-arrayexpress
TranscriptomicsG-CSF receptor targeting in inflammatory arthritis
G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation and function. We developed a neutralizing monoclonal antibody to the murine G-CSF receptor (G-CSFR), which antagonizes binding of murine G-CSF and inhibits G-CSFR signallin...
ORGANISM(S): Mus musculus 
2016-01-19 | E-GEOD-76966 | biostudies-arrayexpress
TranscriptomicsG-CSF plus AMD3100 mobilization in adult patients with beta-thalassemia results in effective mobilization of CD34+ cells with primitive signatures
Successful gene therapy for β-thalassemia requires optimal numbers of autologous gene-transduced hematopoietic progenitors stem cells (HPSC) with high repopulating capacity and mobilization is the optimal approach for achieving this goal. We performed a clinical study to investigate safety and effi...
ORGANISM(S): Homo sapiens 
2017-04-28 | E-GEOD-70219 | biostudies-arrayexpress
TranscriptomicsHypothalamic gene expression profile indicates a reduction in G-protein signaling in the wfs1 mutant mice
WFS1 gene is coding protein with unknown function but its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by the Wfs1 deficiency in the hypothalamus. We performed gene expression profiling ...
ORGANISM(S): Mus musculus 
2011-11-02 | E-GEOD-33372 | biostudies-arrayexpress
no omics definedTranscription profiling of human macrophages treated with lipopolysaccharide plus INF-g, IL-10 or rhAPC
Macrophages treated with INF-g (100 U/ml)and LPS (10 ng/ml), or INF-g (100 U/ml), LPS (10 ng/ml)and IL-10 (5 ng/mL), or INF-g (100 U/ml), LPS (10 ng/ml)and rhAPC(5 ug/mL. Each treatment is hybridized against untreated macrophages
ORGANISM(S): Homo sapiens 
2007-09-27 | E-MEXP-927 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of human cybrid cell lines harboring increasing levels of the mitochondrial DNA (mtDNA) 3243A>G mutation
Mitochondria generate signals of adaptation that regulate nuclear genes expression via retrograde signaling. But this phenomenon is complexified when qualitatively different mitochondria and mitochondrial DNA (mtDNA) coexist within cells. Although this cellular state of heteroplasmy leads to diver...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-56158 | biostudies-arrayexpress
ProteomicsComprehensive identification of proteins binding to RNA G-quadruplex motifs in the 5’ UTR of tumor-associated mRNAs
G-quadruplex structures in the 5’ UTR of mRNAs are widely considered to suppress translation without affecting transcription. The current study describes the comprehensive analysis of proteins binding to four different G-quadruplex motifs located in mRNAs of the cancer-related genes Bcl-2, NRAS, MMP...
ORGANISM(S): Homo sapiens (Human) 
2017-11-14 | PXD005761 | Pride
Nras Cancer Translational regulation Silac Mmp16 Rna Rbps Shotgun proteomics G-quadruplexes Bcl-2 Arpc2 Post-transcriptional regulation 
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