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TranscriptomicsTranscription profiling of mouse Foxp3-expressing regulatory T cells
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant immune tolerance to self. Most Treg cells constitutively express the high-affinity interleukin 2 (IL-2) receptor alpha-chain (CD25); however, the precise function of IL-2 in T...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4179 | biostudies-arrayexpress
TranscriptomicsPrenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis
Developmental exposures play a role in adult onset chronic disease. The mechanisms by which environmental toxicants alter developmental processes predisposing individuals to chronic disease are not understood. arsenic exposure via drinking water causes cancer and cardiovascular disease. Transplacent...
ORGANISM(S): Mus musculus 
2012-06-21 | E-GEOD-30783 | biostudies-arrayexpress
UnknownDenosumab and bone metastasis-free survival in men with nonmetastatic castration-resistant prostate cancer: exploratory analyses by baseline prostate-specific antigen doubling time.
Not available
S-EPMC3795889 | biostudies-literature
TranscriptomicsRNAseq of A375 melanoma cells and A375 with ARID1A KO in control conditions and treatment with trametinib, vemurafenib or combination
The experiment aimed to study mechanisms of melanoma drug resistance. ARID1A confers resistance to trametinib and therefore RNAseq was collected alongside other omics data for parental A375 likes, and A375 lines with ARID1A KO, in the presence of no drug, trametinib, vemurafenib or their combination
ORGANISM(S): Homo sapiens 
2025-02-18 | E-MTAB-14759 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse peripheral T cells subsets: T-N, T-25, T-FN and T-R cells; T-25, T-FN and T-R cells after treatment with IL-2; and T-R cells transduced with empty, PDE3B-expressing or PDE3B(H801A)-expressing retroviral vectors
This data set is comprised of all peripheral (pooled lymph nodes and spleen) T cell subsets presented in this manuscript. These include T-N, T-25, T-FN and T-R cells; T-25, T-FN and T-R cells from mice treated with IL-2; and T-R cells transduced with empty, PDE3B-expressing or PDE3B(H801A)-expressi...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7280 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse thymic T cells - Foxp3-dependent programme of regulatory T-cell differentiation (GEO Super Series0
This SuperSeries is composed of the following subset Series:; GSE7280: Gene expression in peripheral cells: effects of Foxp3 and PDE3B; GSE7770: Gene expression in thymic CD4 T cells: effects of Foxp3 Experiment Overall Design: Thymocyte RNA (GSE7770) was processed with Affy and Enzo reagents wherea...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7773 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of the Arctic springtail Megaphorura arctica after cold or salt dehydration to study insect cyroprotective dehydration
The 13,824 cDNA microarray was constructed by printing 6912 PCR-amplified cDNA clones in duplicate. These were derived from a previous EST study (Clark et al, 2007) and comprised 3840 clones from the Library D2 (fully dehydrated animals, cooled to -14°C) and 3072 clones from the Library D1 (dehydrat...
ORGANISM(S): Megaphorura arctica 
2009-07-21 | E-MEXP-2105 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Laternula elliptica under heat stress
Microarray analysis of gene expression in the Antarctic clam Laternula elliptica after exposure to elevated temperatures
ORGANISM(S): Laternula elliptica 
2010-08-03 | E-MEXP-2336 | biostudies-arrayexpress
TranscriptomicsGene expression in response to axotomy in organotypical slices co-cultures
Brain slice cultures offer advantages over other in vitro methods, as they mimic numerous in vivo aspects. For most purposes, slices of the developing brain, termed organotypic slice cultures , preserve a high degree of cellular differentiation and tissue organization. The entorhino-hippocampal conn...
ORGANISM(S): Rattus norvegicus 
2011-02-25 | E-GEOD-20528 | biostudies-arrayexpress
GenomicsAorta- and liver-specific ERalpha binding patterns and gene regulation by estrogen (ChIP-seq)
Estrogen has vascular protective effects in premenopausal women and in women under 60 receiving hormone replacement therapy. However, estrogen also increases risks of breast and uterine cancers and of venous thromboses linked to upregulation of coagulation factors in the liver. In mouse models, the ...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-52351 | biostudies-arrayexpress
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