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ProteomicsProphylactic or therapeutic NAD+ repletion can prevent or rescue HFpEF, but dietary intervention and weight loss cannot
Left ventricular (LV) diastolic dysfunction is a hallmark of Heart Failure with preserved Ejection Fraction (HFpEF), an escalating global health challenge. We demonstrated selective depletion of the oxidized form of nicotinamide adenine dinucleotide (NAD+) and the rate-limiting enzyme of the NAD+ bi...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD033027 | Pride
Mouse Heart 
TranscriptomicsTranscriptional profiling of Escherichia coli after addition of CO gas to aerobically and anaerobically growing cells
Escherichia coli strain MG1655 was grown in a New Brunswick Scientific Bioflow III Biofermentor under continuous culture (chemostat) conditions. Cells were grown in Evans media containing 2 mM glucose as the sole and limiting source of energy and carbon. The working volume was 200 ml, and the diluti...
ORGANISM(S): Escherichia coli 
2016-09-01 | E-GEOD-50713 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of fathead minnows (Pimephales promelas) following an acute exposure to pulp and paper mill effluents
We evaluated the possible mechanisms by which exposure to a sequentially treated pulp and paper mill effluent affects gene expression in the liver of male and female fathead minnows. Sexually mature fathead minnows were exposed to either river water, which served as our control (C), 10% untreated kr...
ORGANISM(S): Pimephales promelas 
2012-12-31 | E-GEOD-25928 | biostudies-arrayexpress
GenomicsH2A.Z.1 mono-ubiquitylation antagonizes BRD2 to maintain poised chromatin in ESCs [ChIP-seq]
Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in ESCs to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigate the function of H2A.Z.1 mono-ubiquitylation (H2A.Z.1ub) by mutation of the PRC1 ...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-53206 | biostudies-arrayexpress
TranscriptomicsSex differences in the translatome of Drosophila fruitless-expressing neurons that underlie reproductive behaviors
Adult reproductive behaviors in Drosophila melanogaster males and females are vastly different. Yet, neurons that express sex-specifically spliced fruitless transcripts (fru P1) underlie these behaviors in both sexes. How the same set of neurons can drive such different behaviors is an important an...
ORGANISM(S): Drosophila melanogaster 
2015-09-01 | E-GEOD-67743 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of Rattus norvegicus brain hippocampal CA1 regions after kainic acid induced status epilepticus and untreated controls.
In this study we used microarray analysis to reveal the gene expression profile of the hippocampal CA1 subregion, which was laser-capture microdissected one week after kainic acid (KA)-induced status epilepticus (SE) in postnatal day 21 (P21) rats. These rats are developmentally roughly comparable t...
ORGANISM(S): Rattus norvegicus 
2010-10-25 | E-TABM-881 | biostudies-arrayexpress
TranscriptomicsRat model of MTLE: Animals with epilepsy vs animals without epilepsy (Agilent)
Neither the molecular basis of the pathologic tendency of neuronal circuits to generate spontaneous seizures (epileptogenicity) nor anti-epileptogenic mechanisms that maintain a seizure-free state are well understood. Here, we performed transcriptomic analysis in the intrahippocampal kainate model o...
ORGANISM(S): Rattus norvegicus 
2011-02-13 | E-GEOD-27015 | biostudies-arrayexpress
TranscriptomicsEstrogen receptor regulation of the social transcriptome
We investigated the gene regulatory network of the estrogen receptor in the preoptic region of dominant and subordinate male Astatotilapia burtoni. We compared dominant males receiving either an ER antagonist or vehicle control and seperately compared subordinate males receiving either an ER antago...
ORGANISM(S): Haplochromis burtoni 
2011-04-13 | E-GEOD-28508 | biostudies-arrayexpress
UnknownElevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.
Not available
S-EPMC7405878 | biostudies-literature
TranscriptomicsTranscription profiling of mouse colonic goblet cells deficient in Atg5
Purpose of this experiment was to gain insight into the transcriptional changes resulting from Atg5 deficiency in colonic goblet cells.
ORGANISM(S): Mus musculus 
2010-09-30 | E-TABM-815 | biostudies-arrayexpress
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