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MetabolomicsTargeted plasma metabolomics combined with machine learning for the diagnosis of acute SARS-CoV-2

The routine clinical diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely restricted to real-time reverse transcription polymerase chain reaction (RT-qPCR), and tests that detect SARS-CoV-2 nucleocapsid antigen. Given the diagnostic delay and suboptimal sensitivity...

2024-08-26 | MTBLS6739 | MetaboLights
TranscriptomicsEffects of fertility on gene expression and function of the bovine endometrium
To identify heifers of contrasting fertility, serial rounds of artificial insemination (AI) were conducted in 201 synchronized crossbred beef heifers. The heifers were then fertility classified based on number of pregnancies detected on day 35 in the four AI opportunities. The reproductive tracts ...
ORGANISM(S): Bos taurus 
2013-04-23 | E-GEOD-46274 | biostudies-arrayexpress
TranscriptomicsThe MLH1 c.-27C>A and c.85G>T variants are borne on a European ancestral haplotype which underlies an autosomal dominant form of MLH1 epimutation.
Lynch syndrome, caused by germline heterozygous mutations of the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2, or deletions affecting the EPCAM gene upstream of MSH2, is characterized by a predisposition to early-onset colorectal and additional extracolonic cancers. An alternative but rare ca...
ORGANISM(S): Homo sapiens 
2013-04-01 | E-GEOD-45149 | biostudies-arrayexpress
TranscriptomicsDamID from Drosophila CNS with Dam fused FruMA, FruMB, FruMC.
In Drosophila,male courtship behaviour serves as an excellent paradigm to study how innate behaviors are controlled by the nervous system. These behaviors are in large part regulated by the gene fruitless (fru). fru encodes a set of putative transcription factors that promote male sexual behaior by ...
ORGANISM(S): Drosophila melanogaster 
2014-01-16 | E-GEOD-52247 | biostudies-arrayexpress
TranscriptomicsMurine E9.5 embryo PSM and newly formed somites: Paraxis-/- vs WT
Transcriptional profiling of E9.5 mouse embryo tissue from the presomitic mesoderm (PSM) and somites I-IV. Tissue from embryos lacking a functional Paraxis gene (Paraxis-/-) was compared to identical tissue from E9.5 Wild Type embryos. The goal was to identify genes that had become deregulated in th...
ORGANISM(S): Mus musculus 
2013-12-05 | E-GEOD-47905 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse liver tissue from SKH:QS mice treated with 68ZnO sunscreens
ZnO nanoparticles can elicit a range of perturbed cell responses in vitro. Exposure to topically applied sunscreens containing ZnO particles may or may not elicit a biological effect in mice. We aimed to determine whether exposure to topically applied ZnO particles manufactured as either microparti...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-46568 | biostudies-arrayexpress
TranscriptomicsExpression data from human olfactory neurosphere derived cells (hONS) established from adult donors treated with coated and uncoated ZnO nanoparticles
ZnO nanoparticles can elicit a range of cytotoxic responses in different cells in vitro that may reflect either Zn2+ dissolution or nanoparticle-specific effects. Coating the ZnO nanoparticles may mitigate their cytotoxicity. We aimed to capture whole genome transcriptional profiles (up and down re...
ORGANISM(S): Homo sapiens 
2013-09-11 | E-GEOD-45322 | biostudies-arrayexpress
TranscriptomicsExpression data from primary human hepatic stellate cells treated with coated and uncoated ZnO nanoparticles, or ZnSO4
ZnO nanoparticles can elicit a range of perturbed cell responses in vitro. The liver is a target for ZnO nanoparticle-, or Zn2+ released from ZnO nanoparticles-induced accumulation and/or impact in vitro and in vivo. The response of human hepatic stellate cells to ZnO nanoparticles has not yet been ...
ORGANISM(S): Homo sapiens 
2014-08-07 | E-GEOD-60159 | biostudies-arrayexpress
TranscriptomicsSingle cell long read genotyping of transcripts reveals discrete mechanisms of clonal evolution in post-MPN AML
Myeloproliferative neoplasm (MPN) or post-MPN acute myeloid leukemia patient bone marrow aspirates were sorted for CD34+ hematopoietic stem and progenitor cells (HSPCs), followed by 10x 3' single cell RNA sequencing and long read sequencing to study the consequences of mutation combination on HSPCs.
ORGANISM(S): Homo sapiens 
2026-06-25 | E-MTAB-15981 | biostudies-arrayexpress
TranscriptomicsCharacterization of primary models of human trophoblast
To understand the human placenta development, we investigated the features of two trophoblast models, trophoblast organoids and trophoblast stem cells, with the aim of identifying which type of trophoblast in vivo they most closely resemble. To this end, we profiled the microRNAs from the two models...
ORGANISM(S): Homo sapiens 
2021-10-18 | E-MTAB-10438 | biostudies-arrayexpress
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