Na+/H+ exchanger 1 (NHE1; SLC9A1) is a transport protein responsible for pH regulation in various types of cells. In cardiac myocytes, NHE1 generates the largest transmembrane acid-extrusion flux and is therefore the most significant controller of the intracellular acid/base milieu. The protein itse...
T-cell acute lymphoblastic leukemia (T-ALL) remains incurable for many patients who relapse, largely because conventional chemotherapy fails to eradicate leukemia stem cells (LSCs). To uncover druggable LSC dependencies, we leveraged an LSC-enriched transgenic zebrafish T-ALL model to screen 773 FDA...
Pancreatic ductal adenocarcinoma (PDAC) progresses in an organ with a unique pH landscape, where the stroma acidifies after each meal. We hypothesized that disrupting this pH landscape during PDAC progression triggers pancreatic stellate cells (PSCs) and cancer-associated fibroblasts (CAFs) to induc...
