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MetabolomicsMicrobiota-derived metabolites act as ecological effectors of colonization resistance against Salmonella Enteritidis

Colonization resistance is a fundamental ecological function of the gut microbiota that limits the expansion of enteric pathogens. Yet, the microbial effectors linking ecosystem homeostasis to pathogen control remain poorly understood. Here, we demonstrate that Salmonella Enteritidis (S. Enteriti...

2026-08-31 | MTBLS15505 | MetaboLights
TranscriptomicsAmplification of RANK- and c-Met-mediated signaling promotes metastatic colonization
We found that RANKL, expressed by cancer cells or derived from exogenous sources, consistently induced human prostate, breast, kidney, lung and liver cancer cells to colonize or metastasize to bone in an animal model of cancer bone metastasis. RANK-mediated signaling established a premetastatic nich...
ORGANISM(S): Homo sapiens 
2014-02-06 | E-GEOD-48432 | biostudies-arrayexpress
ProteomicsTemporal multi-omics identifies LRG1 as vascular instructor of early metastatic colonization.
Metastasis is the primary cause of cancer-related mortality and the mechanistically least well understood step of the tumor progression cascade. Employing surgical preclinical metastasis models, we show here that small primary tumors reprogram the body’s vascular endothelium to alter systemic homeos...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-16 | PXD013978 | Pride
And vascular niche Lrg1 Endothelial cells Cancer Metastasis 
GenomicsOrgan-Specific Colonization and Niche Remodeling in a Human Tissue Model of Metastasis
Organ-Specific Colonization and Niche Remodeling in a Human Tissue Model of Metastasis
PRJNA1465898 | ENA
TranscriptomicsGenomic variations define divergence of water/wildlife-associated Campylobacter jejuni niche specialists from common clonal complexes
Although the major food-borne pathogen Campylobacter jejuni has been isolated from diverse animal, human and environmental sources, our knowledge of genomic diversity in C. jejuni is based exclusively on human or human food-chain-associated isolates. Studies employing multilocus sequence typing have...
ORGANISM(S): Campylobacter jejuni 
2011-04-15 | E-BUGS-95 | biostudies-arrayexpress
TranscriptomicsThe metabolic niche of a prominent sulfate-reducing human gut bacterium [3]
Sulfate-reducing bacteria (SRB) colonize the guts of ~50% of humans. We used genome-wide transposon mutagenesis and insertion-site sequencing (INSeq), RNA-Seq, plus mass spectrometry to characterize genetic and environmental factors that impact the niche of Desulfovibrio piger, the most common SRB i...
ORGANISM(S): Mus musculus 
2013-07-12 | E-GEOD-48808 | biostudies-arrayexpress
UnknownThe osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.
Not available
S-EPMC4326554 | biostudies-literature
UnknownMesenchymal Cancer Cell-Stroma Crosstalk Promotes Niche Activation, Epithelial Reversion, and Metastatic Colonization.
Not available
S-EPMC4695340 | biostudies-literature
UnknownPollination niche availability facilitates colonization of Guettarda speciosa with heteromorphic self-incompatibility on oceanic islands.
Not available
S-EPMC6137094 | biostudies-literature
UnknownExtracellular matrix mediators of metastatic cell colonization characterized using scaffold mimics of the pre-metastatic niche.
Not available
S-EPMC4777643 | biostudies-literature
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