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Distinct shaping of the upper versus lower facial skeleton is essential for function of the vertebrate jaw and middle ear, yet the cellular mechanisms by which this occurs have remained unclear. Here, we show that Endothelin1 (Edn1) signaling accelerates mesenchymal condensation and subsequent carti...
ORGANISM(S): Danio rerio 
Gene Expression Analysis for Modelling Immune Trajectory and Endotype Transition During Pediatric Septic Shock We aimed to characterise the immune trajectory of 19 children with septic shock from first interaction with pediatric critical care teams (TP1) to 48 hours afterwards (TP2). We analysed da...
ORGANISM(S): Homo sapiens 
There is considerable evidence that inhibition of p38α mitogen-activated protein kinase diminishes cardiac damage during myocardial ischemia. During myocardial ischemia p38α interacts with TAB1, a scaffold protein, which promotes p38α autoactivation; active p38α (pp38α) then trans-phosphorylates TAB...
ORGANISM(S): Mus musculus 
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