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TranscriptomicsNanopore RNA-seq of human cell lines treated with or without nicotinamide adenine dinucleotide (NAD+)
Investigation of transcriptome changes in four human cell lines (BJ, BJ-5ta, U2OS and HeLa) after treatment for 24 hours with nicotinamide adenine dinucleotide (NAD+). Cells were untreated as the control condition. Nanopore sequencing of cDNA was performed after library preparation with the ONT SQK...
ORGANISM(S): Homo sapiens 
2023-09-20 | E-MTAB-13187 | biostudies-arrayexpress
MetabolomicsNR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease

Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To ev...

2025-04-09 | MTBLS8812 | MetaboLights
ProteomicsNAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes
Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms. Nicotinamide adenine dinucleotide kinase (NADK) is the only enzyme that catalyzes synthesis of NADP(H) from NAD...
ORGANISM(S): Staphylococcus aureus 
2022-08-12 | PXD032968 | Pride
Staphylococcus aureus Nicotinamide adenine dinucleotide kinase 
TranscriptomicsNicotinamide mononucleotide, a key NAD+ precursor, treats the pathophysiology of diet- and age-induced diabetes
Type 2 diabetes (T2D) has become an epidemic in our modern lifestyle, likely due to calorie-rich diets overwhelming our adaptive metabolic pathways. One such pathway is mediated by nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in mammalian NAD+ biosynthesis, and the NAD+-...
ORGANISM(S): Mus musculus 
2011-12-05 | E-GEOD-31647 | biostudies-arrayexpress
TranscriptomicsExpression profiles of Actinobacillus pleuropneumoniae 4074 and the qseB/qseC gene-deleted mutant
To determine the role of Actinobacillus pleuropneumoniae two-component system QseBQseC, we constructed a qseBqseC gene-deleted mutant ΔqseBΔqseC based on the wild type A. pleuropneumoniae 4074. The transcriptional profiles were compared between the A. pleuropneumoniae ΔqseBΔqseC and its parental str...
ORGANISM(S): Actinobacillus pleuropneumoniae 
2014-08-01 | E-GEOD-49812 | biostudies-arrayexpress
MetabolomicsResting natural killer cell homeostasis relies on tryptophan/NAD+ metabolism and HIF-1α

Natural killer (NK) cells are forced to cope with different oxygen environments even under resting conditions. The adaptation to low oxygen is regulated by oxygen-sensitive transcription factors, the hypoxia-inducible factors (HIFs). The function of HIFs for NK cell activation and metabolic rewir...

2023-06-01 | MTBLS6863 | MetaboLights
UnknownDiabetic complications within the context of aging: Nicotinamide adenine dinucleotide redox, insulin C-peptide, sirtuin 1-liver kinase B1-adenosine monophosphate-activated protein kinase positive feedback and forkhead box O3.
Not available
S-EPMC4931191 | biostudies-literature
TranscriptomicsNicotinamide Starvation of Mycobacteria Defective for de novo NAD Biosynthesis
Mycobacteria can synthesize NAD+ using either the de novo biosynthesis pathway or the salvage pathway. The deletion of the three genes involved specifically in the NAD+ de novo biosynthesis pathway in the human pathogen Mycobacterium tuberculosis had no effect on the growth of the strain in vivo. ...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-14 | E-GEOD-18909 | biostudies-arrayexpress
UnknownImpaired nicotinamide adenine dinucleotide (NAD+ ) metabolism in diabetes and diabetic tissues: Implications for nicotinamide-related compound treatment.
Not available
S-EPMC7610120 | biostudies-literature
TranscriptomicsExpression data of Actinobacillus pleuropneumoniae 4074 and the M-NM-^TluxS mutant of Actinobacillus pleuropneumoniae 4074
LuxS is an enzyme involved in the activated methyl cycle and the by-product autoinducer 2 (AI-2) was a quorum sensing signal in some species. In our previous study, the functional LuxS in AI-2 production was verified in the porcine respiratory pathogen Actinobacillus pleuropneumoniae. Enhanced biofi...
ORGANISM(S): Actinobacillus pleuropneumoniae 
2011-11-09 | E-GEOD-19056 | biostudies-arrayexpress
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