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TranscriptomicsTranscription profiling by array of brain from zebrafish treated with ethanol or nicotine suggests conservation of neuro-adaptation pathways
Effect of ethanol or nicotine exposure on gene expression compared to control. Duplicate arrays from ethanol or nicotine treated animals compared with triplicate arrays from paired control animals. In total 4 treatment arrays (2 ethanol, 2 nicotine) and 3 control arrays (from control animals treate...
ORGANISM(S): Danio rerio 
2008-05-01 | E-MEXP-1301 | biostudies-arrayexpress
ProteomicsSex differences in the ventral tegmental area and nucleus accumbens proteome at baseline and following nicotine exposure
Sex differences in behaviors relevant to nicotine addiction have been observed in rodent models and human subjects. Behavioral, imaging and epidemiological studies also suggest underlying sex differences in mesolimbic dopamine signaling pathways. In this study we evaluated the proteome in the ventra...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD023859 | Pride
Sex Nicotine exposure Mouse Vta Nac 
MetabolomicsCadmium acute exposure induces metabolic and transcriptomic perturbations in human mature adipocytes
Obesity is considered as a major public health concern with strong economic and social burdens. Exposure to pollutants such as heavy metals can contribute to the development of obesity and its associated metabolic disorders, including type 2 diabetes and cardiovascular diseases. Adipose tissue is an...
2023-06-29 | MTBLS4128 | MetaboLights
TranscriptomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (RNE)
While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been assessed individually in separate studies, limited data on the inhalation toxicity of them is available when in mixtures. In this 90-day subchron...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5910 | biostudies-arrayexpress
TranscriptomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (Lung)
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5545 | biostudies-arrayexpress
TranscriptomicsToxicity of Toxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (Liver)
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5544 | biostudies-arrayexpress
TranscriptomicsmRNA-Seq of Danio rerio exposed to different concentrations of the insecticide nicotine against untreated control groups
In the present study transcriptome analysis was employed to investigate the early molecular responses to exposure to the insecticide nicotine (CAS 54-11-5). Zebrafish embryos were exposed to nicotine according to OECD guidelines (OECD test No. 236). At the end of exposure time (96 hours), simultaneo...
ORGANISM(S): Danio rerio 
2026-09-30 | E-MTAB-16490 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression of human periodontal ligament derived stem cell line exposed to 1 microMolar (uM) (-)-nicotine liquid or 1 uM nicotine electronic cigarette vapor extract against untreated control
Nicotine and cigarette smoking have been previously shown to inhibit the differentiation potential and miRNA expression of human periodontal ligament derived stem cells (PDLSCs). Electronic cigarette (EC) vapor also contains nicotine, as well as other non-nicotine compounds, and, like cigarette smok...
ORGANISM(S): Homo sapiens 
2019-09-30 | E-MTAB-7893 | biostudies-arrayexpress
TranscriptomicsDevelopmental nicotine mediated gene expression and epigenetic change effects on neuronal structure and behavior [gene expression]
Developmental nicotine exposure causes persistent changes in cortical neuron morphology and in behavior. We used microarray screening to identify master transcriptional or epigenetic regulators mediating these effects of nicotine mRNA prepared from dissected cortical tissue from mice that were admin...
ORGANISM(S): Mus musculus 
2016-05-30 | E-GEOD-80787 | biostudies-arrayexpress
TranscriptomicsBiological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen® cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up t...
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10166 | biostudies-arrayexpress
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