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TranscriptomicsHigh throughput sequencing of the mouse transcriptome within the VTA following exposure to emotional stress.
Using a novel stress paradigm, we generated emotionally stressed, physically stressed, and control animals. We measured changes in mRNA expression using Illumina HiSeq2000 to obtain high-depth sequencing. Interestingly, we observed a number of significantly up- and down-regulated mRNAs. By identi...
ORGANISM(S): Mus musculus 
2012-08-21 | E-GEOD-36005 | biostudies-arrayexpress
TranscriptomicsAge-mediated transcriptomic changes in adult mouse brain ventral tegmental area
Substantia nigra pars compacta (SNpc) is highly sensitive to normal aging and selectively degenerates in Parkinson's disease. However, ventral tegmental area (VTA), a region adjacent to SNpc, is less affected in PD. Until now, molecular mechanisms behind VTA aging have not been fully investigated us...
ORGANISM(S): Mus musculus 
2013-05-29 | E-GEOD-45044 | biostudies-arrayexpress
TranscriptomicsVTA neurons show an adaptive transcriptional response to MPTP which differs from SN neurons
Implications for neuroprotection in Parkinson's disease Parkinson’s disease and its characteristic symptoms are thought to arise from the progressive degeneration of specific midbrain dopamine (DA) neurons. In humans, DA neurons of the substantia nigra (SN) and their projections to the striatum sh...
ORGANISM(S): Mus musculus 
2009-12-31 | E-GEOD-17542 | biostudies-arrayexpress
TranscriptomicsPatchSeq experiment on somatostatin-expressing (Sst) neurons from mouse ventral tegmental area (VTA). Full-length single cell sequencing.
Experiment was done as a part of multi-methodological description of Sst-neurons subtypes in mouse VTA, aiming to reveal their transcriptional profiles and neurotransmitter nature.
ORGANISM(S): Mus musculus 
2020-06-02 | E-MTAB-8780 | biostudies-arrayexpress
Genomics24-hour transcriptome profile in the murine VTA
24-hour transcriptome profile in the murine VTA
PRJNA517615 | ENA
GenomicsStress resilience is associated with transcriptional remodeling in the VTA
Stress resilience is associated with transcriptional remodeling in the VTA
PRJNA1295774 | ENA
ProteomicsSex differences in the ventral tegmental area and nucleus accumbens proteome at baseline and following nicotine exposure
Sex differences in behaviors relevant to nicotine addiction have been observed in rodent models and human subjects. Behavioral, imaging and epidemiological studies also suggest underlying sex differences in mesolimbic dopamine signaling pathways. In this study we evaluated the proteome in the ventra...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-28 | PXD023859 | Pride
Sex Nicotine exposure Mouse Vta Nac 
Transcriptomics24-hour transcriptome profile in the murine VTA
This study aimed at identifying rhythmically regulated transcripts in the ventral tegmental area (VTA) of mice. Punch biopsies of the VTA from C57BL/6 brain slices were prepared at 6 different timepoints across the day and analyzed for transcriptome regulation
ORGANISM(S): Mus musculus 
2019-01-30 | GSE125812 | GEO
GenomicsPersistent open chromatin state in early-life stress-activated cells of the VTA
Persistent open chromatin state in early-life stress-activated cells of the VTA
PRJNA1117426 | ENA
TranscriptomicsTranscription profiling of rat brain samples to compare SNc and VTA dopaminergic neurons in relation to Parkinsons disease
The cardinal clinical features of Parkinson's disease (PD) (rigidity, rest tremor, bradykinesia, and postural instability) result from selective loss of midbrain dopaminergic neurons. More specifically, dopaminergic neurons in the substantia nigra pars compacta (SNc) are much more susceptible to da...
ORGANISM(S): Rattus norvegicus 
2007-09-13 | E-GEOD-1837 | biostudies-arrayexpress
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