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ProteomicsProteomics link translational reprogramming to S-glutathionalytion and induced priming during cold acclimation in barley roots
Plants due to their sessile nature rely on root systems to mediate many challenging stimuli. A major cornerstone of the responses are root proteomes, shaped to overcome biotic and abiotic cues. Proteome-wide reprogramming events are magnified in root meristems due to their active protein production....
ORGANISM(S): Hordeum vulgare (Barley) 
2021-04-14 | PXD021731 | Pride
Barley  cv keel  proteins  cold acclimation  fungal stress  root meristem  proteomics  ribosome  priming elicitors  chitin  chitosan 
ProteomicsLoss of Mitochondrial Fatty Acid β-Oxidation Protein Short Chain Enoyl-CoA Hydratase Disrupts Oxidative Phosphorylation Protein Complex Stability and Function
Short chain enoyl-CoA hydratase 1 (ECHS1) is involved in the second step of mitochondrial fatty acid β-oxidation (FAO), catalysing the hydration of short chain enoyl-CoA esters to short chain 3-hyroxyl-CoA esters. Genetic deficiency in ECHS1 (ECHS1D) is associated with a specific subset of Leigh Syn...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2023-05-10 | PXD032761 | Pride
Mitochondria Oxphos Mitochondrial disease Echs1 deficiency Short chain enoyl-coa hydratase Fatty acid oxidation 
ProteomicsA census of Hsp70-mediated proteome solubility changes upon recovery from severe heat stress
Eukaryotic cells respond to heat shock through several regulatory processes including upregulation of stress responsive chaperones and reversible shutdown cellular activities through formation of protein assemblies. However, the underlying regulatory mechanisms of the recovery of these heat-induced ...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-08 | PXD030069 | Pride
Heat shock protein 70 Disaggregation Heat shock Recovery Chaperone Protein solubility 
UnknownDevelopment of a broad-spectrum subunit vaccine against H9N2 avian influenza using HA stem domain scaffold and snoopligase system.
H9N2 avian influenza virus (AIV) is a globally prevalent pathogen that causes economic losses in poultry and poses zoonotic threats. Due to antigenic drift and shift, traditional inactivated vaccines often show reduced efficacy. This study presents a novel subunit vaccine based on a conserved HA6 sc...
S-EPMC12217984 | biostudies-literature
UnknownThe Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model.
Type 2 diabetes (T2D) is a major chronic healthcare concern worldwide. Emerging evidence suggests that a histone-modification-mediated epigenetic mechanism underlies T2D. Nevertheless, the dynamics of histone marks in T2D have not yet been carefully analyzed. Using a mass spectrometry-based label-fr...
S-EPMC5500764 | biostudies-literature
UnknownControlled intracellular aggregation of magnetic particles improves permeation and retention for magnetic hyperthermia promotion and immune activation.
Rationale: Magnetic nanoparticles (MNPs) are the most used inorganic nanoparticles in clinics with therapeutic and imaging functions, but the inefficient magneto-thermal conversion efficiency, fast leakage, and uneven distribution impair their imaging sensitivity and therapeutic efficacy in t...
S-EPMC10008738 | biostudies-literature
UnknownCapture of Totipotency in Mouse Embryonic Stem Cells in the Absence of Pdzk1.
Totipotent cells can differentiate into three lineages: the epiblast, primitive endoderm, and trophectoderm. Naturally, only early fertilized embryos possess totipotency, and they lose this ability as they develop. The expansion of stem cell differentiation potential has been a hot topic in developm...
S-EPMC11809344 | biostudies-literature
ProteomicsAK9 causes asthenozoospermia and male infertility
Deficiency in AK9 causes asthenozoospermia and male infertility by destabilizing sperm nucleotide homeostasis
ORGANISM(S): Homo Sapiens 
PXD043689 |
UnknownThe Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget's disease.
Mammary and extramammary Paget's Diseases (PD) are a malignant skin cancer characterized by the appearance of Paget cells. Although easily diagnosed, its pathogenesis remains unknown. Here, single-cell RNA-sequencing identified distinct cellular states, novel biomarkers, and signaling pathways - inc...
S-EPMC7608215 | biostudies-literature
UnknownAn atlas of DNA methylomes in porcine adipose and muscle tissues.
It is evident that epigenetic factors, especially DNA methylation, have essential roles in obesity development. Here, using pig as a model, we investigate the systematic association between DNA methylation and obesity. We sample eight variant adipose a...
S-EPMC3508711 | biostudies-literature
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