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TranscriptomicsB bifidum actively changes the gene expression profile induced by L acidophilus in murine dendritic cells
Dendritic cells (DC) play a pivotal regulatory role in activation of the innate as well as the adaptive part of the immune system by responding to environmental microorganisms. We have previously shown that some lactobacilli strains induce a strong production of the pro-inflammatory and Th1 polarizi...
ORGANISM(S): Mus musculus 
2010-02-24 | E-GEOD-20302 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis mutants mpk4 and ctr1
Arabidopsis MPK4 is involved in the control of antagonism between salicylic acid (SA) and ethylene (ET)/jasmonic acid (JA) pathways in the plant innate immune system as a repressor of the SA pathway, but an activator of the ET/JA pathway. Here we and use comparative microarray analysis of ctr1, ctr1...
ORGANISM(S): Arabidopsis thaliana 
2005-08-01 | E-MEXP-174 | biostudies-arrayexpress
MetabolomicsIsotope Labeled Reactivity-Based Metabolomics Reveal Cysteine as a Potent In Vivo Scavenger of Lactoylglutathione

Metabolite adducts are increasingly being recognized as important intermediates in cellular metabolism and as circulating messengers. Methylglyoxal (MG) is a highly reactive metabolite involved in diabetes and aging, via formation of a wide variety of protein adducts. Though new types of protein ...

2025-04-29 | MTBLS6287 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis wild type, 35S:mks1 and mpk4 plants
In plants, MAPKs are implicated in signalling cascades regulating immediate as well as systemic responses to pathogens. Arabidopsis MAP kinase 4 (MPK4) negatively regulates systemic acquired resistance (SAR) accompanied by the expression of pathogenesis-related (PR) genes. MPK4 interacts with and ph...
ORGANISM(S): Arabidopsis thaliana 
2005-09-01 | E-MEXP-173 | biostudies-arrayexpress
GenomicsSpark: A navigational paradigm for genomic data exploration
Biologists possess the detailed knowledge critical for extracting biological insight from genome-wide data resources and yet they are increasingly faced with non-trivial computational analysis challenges posed by genome-scale methodologies. To lower this computational barrier, particularly in the ea...
ORGANISM(S): Homo sapiens 
2012-11-06 | E-GEOD-39096 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae exposed to the sudden addition of glucose - short term perturbation
Study of the short term (within the first 330 seconds) transcriptional response of S.cerevisiae upon a sudden addition of glucose. Experiment Overall Design: Chemostat cultivation – Saccharomyces cerevisiae (CEN PK 113-7D) was cultivated in an aerobic carbon-limited chemostat culture in a 7-litr...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-12 | E-GEOD-3821 | biostudies-arrayexpress
TranscriptomicsiRNA-seq: Computational method for genome wide assessment of acute transcriptional regulation from total RNA-seq data
RNA-seq is a sensitive and accurate technique to compare steady state levels of RNA between different cellular states. However, as it does not provide an account of transcriptional activity per se, other technologies are needed to more precisely determine acute transcriptional responses. Here, we ha...
ORGANISM(S): Homo sapiens 
2015-02-04 | E-GEOD-60462 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces response to lactic acid in anaerobic chemostat cultures
Raw expression values (CHP data) for transcriptional profiling of the response of Saccharomyces cerevisiae to challenges with lactic acid at pH 3 and pH 5. Experiment Overall Design: The laboratory reference strain CEN.PK 113-7D (MATa) was grown at 30 °C in 1.5-L chemostat fermentors (Applikon, Sch...
ORGANISM(S): Saccharomyces cerevisiae 
2008-10-20 | E-GEOD-10066 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae response to weak organic acids in chemostat cultures
Raw expression values (CHP data) for transcriptional profiling of the response of Saccharomyces cerevisiae to challenges with various weak organic acids Experiment Overall Design: The laboratory reference strain CEN.PK 113-7D (MATa) was grown at 30 °C in 2-L chemostat fermentors (Applikon, Schiedam...
ORGANISM(S): Saccharomyces cerevisiae 
2009-04-23 | E-GEOD-5926 | biostudies-arrayexpress
MetabolomicsGlycaemic variability identified as a critical determinant of myocyte dysfunction and risk for myocardial injury in preclinical models of diabetes
Heart disease is the leading cause of morbidity and mortality in individuals with diabetes, due largely to risks associated with ischaemic injuries such as myocardial infarction (MI). We use human population genetic data to demonstrate that current biomarkers of hyperglycaemia do not account for ris...
2026-02-06 | MTBLS11411 | MetaboLights
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