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MetabolomicsPrediction of complex phenotypes using the Drosophila melanogaster metabolome
Understanding the genotype-phenotype map and how variation at different levels of biological organization is associated are central topics in modern biology. Fast developments in sequencing technologies and other molecular omic tools enable researchers to obtain detailed information on variation at ...
2021-08-05 | MTBLS2060 | MetaboLights
TranscriptomicsMolecular architecture of transcription factor hotspots in early adipogenesis
Here, we have used digital genomic footprinting to precisely define protein localization for several adipogenic transcription factors at a genome-wide level. In combination with ChIP-seq data, these analyses reveal novel molecular insight into the organization of transcription factors at hotpot regi...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-57415 | biostudies-arrayexpress
TranscriptomicsThe yeast osmostress response is carbon source dependent
Adaptation to altered osmotic conditions is a fundamental property of living cells and has been studied in particular detail in the yeast Saccharomyces cerevisiae. Yeast cells accumulate glycerol as compatible solute, controlled at different levels by the High Osmolarity Glycerol (HOG) response path...
ORGANISM(S): Saccharomyces cerevisiae 
2017-02-27 | E-MTAB-5313 | biostudies-arrayexpress
TranscriptomicsResponse to different types of stress converge in mitochondrial metabolism
The budding yeast Saccharomyces cerevisiae was used to study 9 different stress conditions in chemostat conditions at constant specific growth rate.
ORGANISM(S): Saccharomyces cerevisiae 
2016-03-01 | E-MTAB-4044 | biostudies-arrayexpress
TranscriptomicsHuman skeletal muscle biopsies from a 3h IL-6 infusion
Skeletal muscle has been identified as a secretory organ. We hypothesized that IL-6, a cytokine secreted from skeletal muscle during exercise, could induce production of other secreted factors in skeletal muscle. Keywords: Human skeletal muscle time course response to IL-6 infusion IL-6 was infused...
ORGANISM(S): Homo sapiens 
2008-05-27 | E-GEOD-10685 | biostudies-arrayexpress
UnknownIdentification of the BRD1 interaction network and its impact on mental disorder risk.
Not available
S-EPMC4855718 | biostudies-literature
UnknownEWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functions.
Not available
S-EPMC4647676 | biostudies-literature
TranscriptomicsDrosophila Imp iCLIP identifies an RNA assemblage co-ordinating F-actin formation
In this study, we employed a combination of RIP-seq and short- and long-wave iCLIP technologies to identify transcripts associated with cytoplasmic RNPs containing the RNA-binding protein Drosophila Imp. We also made a Imp knockdown vs luciferase control experiment. Two biological iCLIP-seq, as well...
ORGANISM(S): Drosophila melanogaster 
2015-05-27 | E-GEOD-62997 | biostudies-arrayexpress
GenomicsAcute Genome-Wide Effects of Rosiglitazone on PPARγ Transcriptional Networks in Adipocytes
Here we report, for the first time, the acute effects of the synthetic PPARγ agonist rosiglitazone on the transcriptional network of PPARγ in adipocytes. Treatment with Rosiglitazone for 1 hour leads to acute transcriptional activation as well as repression of a number of genes as determined by geno...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-49423 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast grown in fermentors at different dilution rates
the protrotophic laboratory strain CEN.PK113-7D (MAT a) was grown in laboratory fermentors with a working volume of 1 litre at dilution rates of 0.02, 0.05, 0.10 (in triplicate), 0.20 (in triplicate), 0.25, and 0.33 per hour (in triplicate). At steady state, samples from each of the 12 continuous cu...
ORGANISM(S): Saccharomyces cerevisiae 
2022-11-21 | E-MEXP-593 | biostudies-arrayexpress
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