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GenomicsDNA-seq of differentially induced promoter regions in E. coli UTI89 strain grown in either J82 bladder epithelial cells, urine, DMEM or LB medium.
The method DFI-seq was developed to enable identification of differentially expressed genes in uropathogenic E. coli strain UTI89 during growth in human urine and in bladder epithelial cells. By utilising this new method, the aim was to identify novel virulence genes in UTI89. DFI-seq is a combinati...
ORGANISM(S): Escherichia coli UTI89 
2017-05-01 | E-MTAB-5657 | biostudies-arrayexpress
TranscriptomicsImmunohistochemical and Clinical Characterization of the Basal-like Subtype
3 fresh frozen Breast tumor from the University of North Carolina at Chapel Hill (UNC) were obtained from the UNC Tissue Procurement Facility under an IRB approved protocol. Each experimental sample was ssayed versus a common reference sample that was a modified version of the Stratagene Human Unive...
ORGANISM(S): Homo sapiens 
2010-06-05 | E-GEOD-1319 | biostudies-arrayexpress
TranscriptomicsPleiotropic roles of Msi1-like protein, Msl1, in growth, differentiation, stress response, and virulence of Cryptococcus neoformans
WD40 motif-containing Msi1-like (MSIL) proteins play pleiotropic cellular functions as a negative regulator of the Ras/cAMP-pathways and a component of chromatin assembly factor-I (CAF-I), and yet have not been studied in fungal pathogens. Here we identified and characterized an MSIL protein, Msl1, ...
ORGANISM(S): Cryptococcus neoformans var. grubii H99 
2012-08-23 | E-GEOD-40303 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Bacillus thuringiensis Bt407 overexpressing transcriptional regulator MogR versus an empty vector (pHT304-Pxyl) control strain during late exponential growth
Comparison in late exponential phase (culture OD600 = 3) of global expression profiles from a Bacillus thuringiensis 407 strain overexpressing transcriptional regulator MogR from xylose inducible vector pHT304-Pxyl, versus an isogenic empty vector control strain, to analyze global expression changes...
ORGANISM(S): Bacillus thuringiensis 
2020-09-28 | E-MTAB-7633 | biostudies-arrayexpress
TranscriptomicsCandida albicans response to spaceflight (NASA STS-115)
This study presents the first global transcriptional profiling and phenotypic characterization of the major human opportunistic fungal pathogen, Candida albicans, grown in spaceflight conditions. Microarray analysis revealed that C. albicans subjected to short-term spaceflight culture differentially...
ORGANISM(S): Candida albicans 
2013-11-01 | E-GEOD-50881 | biostudies-arrayexpress
TranscriptomicsChIP-seq for Leu3 with addition of different levels of leucine, valine and isoleucine
In this experiment we wanted to see how the binding behavior of the S. Cerevisiae transcription factor Leu3, on of the main regulators of leucine biosynthesis, is affected by different availability of the branched chain amino acids. For this we grow the cells in shake flask under glucose limitation ...
ORGANISM(S): Saccharomyces cerevisiae 
2020-07-01 | E-MTAB-8820 | biostudies-arrayexpress
GenomicsGenome-wide mapping of the binding sites of transcription factor Cst6p in Saccharomyces cerevisiae
The transcription factor Cst6p in Saccharomyces cerevisiae has been reported to play important roles in several biological processes. However, the genome-wide targets of Cst6p and the mechanisms for its physiological functions remain unknown. Here, we mapped the genome-wide binding sites of Cst6p wi...
ORGANISM(S): Saccharomyces cerevisiae 
2016-04-04 | E-GEOD-76154 | biostudies-arrayexpress
Genomicsena-DATASET-SFU-20-06-2017-22:32:50:620-88 - samples
This dataset consists of the exome sequencing data for 30 tumour and germline DNA pairs derived from relapsed/refractory DLBCL.
EGAD00001003395 | EGA
GenomicsGenetic landscape of relapsed DLBCL
Diffuse large B-cell lymphoma is a heterogenous malignancy that can arise de novo or can result from histologic transformation from indolent lymphomas. Considerable sequencing effort has been placed on determining the mutations that are common at the time of diagnosis in DLBCL but little is known ab...
EGAS00001001553 | EGA
TranscriptomicsBalancing Protein Folding and Disulfide Bond Formation Rates is Key to Mitigating Secretory Stress
The protein secretory pathway must maintain homoeostasis while producing a wide assortment of proteins in different conditions. It is also used extensively to produce many useful proteins in biotechnology. As such, secretory pathway dysfunction can be highly detrimental to the cell, resulting in ...
ORGANISM(S): Saccharomyces cerevisiae 
2011-12-01 | E-GEOD-27062 | biostudies-arrayexpress
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