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ProteomicsProteomic analysis of monocyte derived macrophages from Niemann-Pick disease type C patients
Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by mutations in Npc1, resulting in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is a prominent pathological feature, direct consequences of NPC1 loss on microglial function remain uncharacterized...
ORGANISM(S): Homo sapiens (Human) 
2021-02-09 | PXD020659 | Pride
Npc Macrophage Lysosomal storage disorder 
ProteomicsProteomics of brain from a myeloid specific NPC1 KO mouse
Niemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly driven by mutations in NPC1 gene, causing lipid accumulation within late endosomes/lysosomes, and resulting in progressive neurodegeneration. Although microglial activation proceeds neuronal loss, it remains elusive ...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-05 | PXD056188 | Pride
Cerebrum Brain Npc1 Cerebellum Mouse Microglia Niemann-pick disease type c 
ProteomicsProteomic signature of NPC1 KO microglia
Niemann-Pick type C (NPC) disease is a rare neurodegenerative disorder mainly caused by autosomal recessive mutations in Npc1 which result in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is one of the prominent pathological features, consequences of NPC1 loss on microglial ...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-09 | PXD019447 | Pride
Npc1 Niemann-pick disease Microglia Neurodegeneration 
ProteomicsProteomic signature of NPC1 KO microglia from conditional KO mice
Niemann-Pick type C (NPC) disease is a rare neurodegenerative disorder mainly caused by autosomal recessive mutations in Npc1 which result in abnormal late endosomal/lysosomal lipid storage. Although microgliosis is one of the prominent pathological features, consequences of NPC1 loss on microglial ...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-09 | PXD019452 | Pride
Mouse Niemann-pick disease Microglia Neurodegeneration 
ProteomicsProteomic analysis of bone-marrow derived macrophages from NPC1 KO mice
Niemann-Pick type C (NPC) disease is an inherited lysosomal storage disorder mainly driven by mutations in NPC1 gene, causing lipid accumulation within late endosomes/lysosomes, and resulting in progressive neurodegeneration. To study the effect of NPC1 deficiency on the innate immune system, we per...
ORGANISM(S): Mus musculus (Mouse) 
2024-12-05 | PXD056249 | Pride
Dia Lysosomal storage disorder Bmdm Npc1 Mouse Niemann-pick disease type c Label free 
UnknownA Global Bibliometric Analysis on Antibiotic-Resistant Active Pulmonary Tuberculosis over the Last 25 Years (1996-2020).
Not available
S-EPMC9405510 | biostudies-literature
UnknownOverlapping Neuroimmune Mechanisms and Therapeutic Targets in Neurodegenerative Disorders.
Not available
S-EPMC10604382 | biostudies-literature
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