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ProteomicsEffects of CerS4 deletion in murine epidermis on proteome and lipidome
Epidermal deletion of the lipid modifying enzyme CerS4 causes epidermal barrier impairments associated with human skin diseases. Proteomes of Wt newborn and P47 mice were compared in order to identify molecular differences between barrier formation and maintenance. Proteomes of epidermal splits from...
ORGANISM(S): Mus musculus (Mouse) 
2020-02-27 | PXD012220 | Pride
Epidermal barrier Lipid homeostasis Barrier maintenance Barrier formation Cers4 Ceramides 
ProteomicsA compound-based therapy approach for epidermolysis bullosa simplex (EBS)
Keratin cytoskeletal proteins are crucial for the maintenance of skin integrity. Mutations in genes coding for K5 and K14 cause the human skin disorder epidermolysis bullosa simplex (EBS) leading to substantial alterations in keratin assembly and collapse of keratin filaments into cytoplasmic protei...
ORGANISM(S): Homo sapiens (Human) 
2022-06-29 | PXD030939 | Pride
Keratins Epidermolysis bullosa simplex Multi-kinase inhibitor Phosphorylation Therapy 
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