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TranscriptomicsInteractions among Polycomb domains are guided by chromosome architecture
Polycomb group (PcG) proteins bind and regulate hundreds of genes. Previous evidence has suggested that long-range chromatin interactions may contribute to the regulation of PcG target genes. Here, we adapted the Chromosome Conformation Capture on Chip (4C) assay to systematically map chromosomal in...
ORGANISM(S): Drosophila melanogaster 
2011-05-09 | E-GEOD-23166 | biostudies-arrayexpress
TranscriptomicsSERPINA6, BEX1, AGTR1, SLC26A3, and LAPTM4B are markers of resistance to neoadjuvant chemotherapy in HER2-negative breast cancer
Abstract Introduction Response rates to chemotherapy remain highly variable in breast cancer patients. We set out to identify genes associated with chemotherapy resistance. We analyzed what is currently the largest single-institute set of gene expression profiles derived from breast cancers prior t...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-34138 | biostudies-arrayexpress
TranscriptomicsGlucosylated hydroxymethyluracil (DNA base J) prevents transcriptional read-through in Leishmania
Some T's in nuclear DNA of trypanosomes and Leishmania are hydroxylated and glucosylated to yield base J (?-D-glucosyl-hydroxymethyluracil). In Leishmania about 99% of J is located in telomeric repeats. We show here that most of the remaining J is located at chromosome-internal RNA Polymerase II ter...
ORGANISM(S): Leishmania major 
2011-10-15 | E-GEOD-32976 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in wild type and In(3LR)sep larval brain tissue (Drosophila)
We performed a series of microarray expression profile experiments in central brain tissue from 3rd instar larvae, interrogating expression differences between wild type and In(3LR)sep strains. Since our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166), demonstrated dramatic chan...
ORGANISM(S): Drosophila melanogaster 
2011-05-09 | E-GEOD-26693 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human cell cultures, MCF7 and SYS5Y, subjected to volatile anesthetic gasses
Human cell cultures (MCF7 and SY5Y) were subjected to volatile anesthetic gasses in an operation theater and monitored for full genome gene expression characteristics to learn more about the time dependent molecular mechanisms that occur during surgery and to find the implications that anesthetics m...
ORGANISM(S): Homo sapiens 
2010-10-10 | E-NCMF-32 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD34+CD38- and CD34+CD38+ cells from patients with acute myelogenous leukemia (AML)
Not available
ORGANISM(S): Homo sapiens 
2008-08-01 | E-NCMF-11 | biostudies-arrayexpress
TranscriptomicsMapping of Polycomb binding in Drosophila larval brain tissue using DamID
We made Polycomb (PC) and histone H3 lysine 27 trimethylation (H3K27me3) chromatin binding maps in central brain tissue from 3rd instar larvae, allowing us to make a direct comparison to our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166). Our results demonstrate that our PC and...
ORGANISM(S): Drosophila melanogaster 
2011-12-31 | E-GEOD-23298 | biostudies-arrayexpress
TranscriptomicsPolycomb chromatin domains in Drosophila
This SuperSeries is composed of the following subset Series: GSE23166: Interactions among Polycomb domains are guided by chromosome architecture GSE26693: Gene expression profiling in wild type and In(3LR)sep larval brain tissue (Drosophila) Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2011-01-31 | E-GEOD-26694 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of a series of HER2+ of breast tumors
Abstract Motivation Breast cancer is a heterogeneous disease with distinct subtypes. Even within these subtypes differences at the molecular level are present which are reflected in variable responses to chemotherapy. We set out to identify genes associated with chemotherapy resistance by analyzing...
ORGANISM(S): Homo sapiens 
2013-10-22 | E-GEOD-41656 | biostudies-arrayexpress
TranscriptomicsMapping of H3K27me3 enrichment in Drosophila larval brain tissue using ChIP-chip
We made Polycomb (PC) and histone H3 lysine 27 trimethylation (H3K27me3) chromatin binding maps in central brain tissue from 3rd instar larvae, allowing us to make a direct comparison to our 4C data (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE23166). Our results demonstrate that our PC and...
ORGANISM(S): Drosophila melanogaster 
2011-12-31 | E-GEOD-23299 | biostudies-arrayexpress
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