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MetabolomicsMetabolomics and lipidomics reveal perturbation of sphingolipid metabolism by a novel anti-trypanosomal 3-(oxazolo[4,5-b]pyridine-2-yl)anilide
Trypanosoma brucei is the causative agent of human African trypanosomiasis, which is responsible for thousands of deaths every year. Current therapies are limited and there is an urgent need to develop new drugs. The anti-trypanosomal compound, 3-(oxazolo[4,5-b]pyridine-2-yl)anilide (OXPA), was init...
2017-10-09 | MTBLS360 | MetaboLights
MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
UnknownNeutrophils are important for the development of pro-reparative macrophages after irreversible electroporation of the liver in mice.
Not available
S-EPMC8298444 | biostudies-literature
UnknownPlasma lipids are dysregulated preceding diagnosis of preeclampsia or delivery of a growth restricted infant.
Not available
S-EPMC10344703 | biostudies-literature
MetabolomicsComparative metabolomics of Mycoplasma bovis and Mycoplasma gallisepticum reveals fundamental differences in active metabolic pathways and suggests novel gene annotations
Mycoplasmas are simple, but successful parasites that have the smallest genome of any free-living cell and are thought to have a highly streamlined cellular metabolism. Here we have undertaken a detailed metabolomic analysis of two species, Mycoplasma bovis and Mycoplasma gallisepticum, which cause ...
2017-10-10 | MTBLS535 | MetaboLights
UnknownSatisfaction can co-exist with hesitation: qualitative analysis of acceptability of telemedicine among multi-lingual patients in a safety-net healthcare system during the COVID-19 pandemic.
Not available
S-EPMC8842908 | biostudies-literature
UnknownMetabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action.
Not available
S-EPMC5075070 | biostudies-literature
UnknownCircadian and wake-dependent changes in human plasma polar metabolites during prolonged wakefulness: A preliminary analysis.
Not available
S-EPMC6418225 | biostudies-literature
UnknownCD98 defines a metabolically flexible, proinflammatory subset of low-density neutrophils in systemic lupus erythematosus.
Not available
S-EPMC9849148 | biostudies-literature
UnknownPlasma metabolites are altered before and after diagnosis of preeclampsia or fetal growth restriction.
Not available
S-EPMC11233654 | biostudies-literature
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