Sort   by:  
 Page size 
UnknownA genomic timescale for placental mammal evolution.
The precise pattern and timing of speciation events that gave rise to all living placental mammals remain controversial. We provide a comprehensive phylogenetic analysis of genetic variation across an alignment of 241 placental mammal genome assemblies, addressing prior concerns regarding limited ge...
S-EPMC10233747 | biostudies-literature
UnknownThe contribution of historical processes to contemporary extinction risk in placental mammals.
Species persistence can be influenced by the amount, type, and distribution of diversity across the genome, suggesting a potential relationship between historical demography and resilience. In this study, we surveyed genetic variation across single genomes of 240 mammals that compose the Zoonomia al...
S-EPMC10184782 | biostudies-literature
UnknownPsychological intervention with working memory training increases basal ganglia volume: A VBM study of inpatient treatment for methamphetamine use.

Background

Protracted methamphetamine (MA) use is associated with decreased control over drug craving and altered brain volume in the frontostriatal network. However, the nature of volumetric changes following a course of psychological intervention for MA use is not yet known.

Methods

S-EPMC5011179 | biostudies-literature
UnknownInter- and intra-rater reliability for measurement of range of motion in joints included in three hypermobility assessment methods.

Background

Comparisons across studies of generalized joint hypermobility are often difficult since there are several classification methods and methodological differences in the performance exist. The Beighton score is most commonly used and has been tested for inter- and intra-rater reliabi...
S-EPMC6192271 | biostudies-literature
UnknownGlobal patterns in endemicity and vulnerability of soil fungi.
Fungi are highly diverse organisms, which provide multiple ecosystem services. However, compared with charismatic animals and plants, the distribution patterns and conservation needs of fungi have been little explored. Here, we examined endemicity patterns, global change vulnerability and conservati...
S-EPMC9826061 | biostudies-literature
Unknown​Comparative genomics of Balto, a famous historic dog, captures lost diversity of 1920s sled dogs.
We reconstruct the phenotype of Balto, the heroic sled dog renowned for transporting diphtheria antitoxin to Nome, Alaska, in 1925, using evolutionary constraint estimates from the Zoonomia alignment of 240 mammals and 682 genomes from dogs and wolves of the 21st century. Balto shares just part of h...
S-EPMC10184777 | biostudies-literature
UnknownLeveraging base-pair mammalian constraint to understand genetic variation and human disease.
Thousands of genomic regions have been associated with heritable human diseases, but attempts to elucidate biological mechanisms are impeded by an inability to discern which genomic positions are functionally important. Evolutionary constraint is a powerful predictor of function, agnostic to cell ty...
S-EPMC10259825 | biostudies-literature
UnknownIntegrating gene annotation with orthology inference at scale.
Annotating coding genes and inferring orthologs are two classical challenges in genomics and evolutionary biology that have traditionally been approached separately, limiting scalability. We present TOGA (Tool to infer Orthologs from Genome Alignments), a method that integrates structural gene annot...
S-EPMC10193443 | biostudies-literature
UnknownRelating enhancer genetic variation across mammals to complex phenotypes using machine learning.
Protein-coding differences between species often fail to explain phenotypic diversity, suggesting the involvement of genomic elements that regulate gene expression such as enhancers. Identifying associations between enhancers and phenotypes is challenging because enhancer activity can be tissue-depe...
S-EPMC10322212 | biostudies-literature
UnknownThe functional and evolutionary impacts of human-specific deletions in conserved elements.
Conserved genomic sequences disrupted in humans may underlie uniquely human phenotypic traits. We identified and characterized 10,032 human-specific conserved deletions (hCONDELs). These short (average 2.56 base pairs) deletions are enriched for human brain functions across genetic, epigenomic, and ...
S-EPMC10202372 | biostudies-literature
Sort   by:  
 Page size