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TranscriptomicsGene expression changes in limb buds of Nipbl-haploinsufficient mice
Multiple genes are dysregulated in hindlimb buds of Nipbl-deficient embryos. In all, more than 1000 limb bud genes were found to be significantly altered in expression by microarray analysis of E10.5 mouse hindlimb buds. Small changes in expression (mostly decreases) were observed for genes involve...
ORGANISM(S): Mus musculus 
2014-08-30 | E-GEOD-60932 | biostudies-arrayexpress
ProteomicsTranscription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers
While the cohesin complex is a key player in genome architecture, how it localizes to specific chromatin sites is not well understood. Recently, we and others have proposed that direct interactions with transcription factors (TFs) lead to the localization of the cohesin-loader complex (NIPBL/MAU2) w...
ORGANISM(S): Mus musculus (Mouse) 
2025-04-17 | PXD058574 | Pride
Cohesin Nipbl Transcription factors Interactome 
TranscriptomicsTranscription profiling of Cornelia de Lange Syndrome proband derived cell lines reveals defective cohesin in cdls mediates gene expression with characteristics of transcription factor and insulator activity
The Cohesin apparatus has a canonical role in sister chromatid cohesion. Heterozygous mutations in Nipped B-like (NIPBL), SMC1A, and SMC3 have been found in 60% of probands with Cornelia de Lange Syndrome (CdLS), a dominant multi-system genetic disorder with variable expression. We have performed a ...
ORGANISM(S): Homo sapiens 
2009-06-08 | E-GEOD-12408 | biostudies-arrayexpress
GenomicsChIP-Seq for NIPBL for SMC1 in human lymphoblastoid cells (hLCLs)
The gene expression program is regulated by a cell-type specific chromosome architecture. The connection between enhancer and promoter regions is dependent on a protein complex containing Nipbl, Mediator and Cohesin. To gain insights into the chromosome architecture of human differentiated cells, we...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-GEOD-38395 | biostudies-arrayexpress
GenomicsRNA-seq of primary dissociated cortical Nipbl+/- neurons
RNA-seq of primary dissociated cortical Nipbl+/- neurons
PRJNA679479 | ENA
GenomicsGenome occupancy of NIPBL in mouse P19 teratocarcinoma cells.
Genome occupancy of NIPBL in mouse P19 teratocarcinoma cells.
PRJNA548964 | ENA
GenomicsRecurrent FOXA1 mutation redirects NIPBL chromatin distribution
Recurrent FOXA1 mutation redirects NIPBL chromatin distribution
PRJNA1396651 | ENA
GenomicsMAU2 and NIPBL variants in Cornelia de Lange syndrome reveal MAU2-independent loading of cohesin and uncover protective mechanisms against early truncating mutations in NIPBL
MAU2 and NIPBL variants in Cornelia de Lange syndrome reveal MAU2-independent loading of cohesin and uncover protective mechanisms against early truncating mutations in NIPBL
PRJNA504541 | ENA
UnknownRegulation of the cohesin-loading factor NIPBL: Role of the lncRNA NIPBL-AS1 and identification of a distal enhancer element.
Not available
S-EPMC5754091 | biostudies-literature
GenomicsDecreasing Wapl dosage partially corrects transcriptome phenotypes in Nipbl-/+ embryonic mouse brain
Decreasing Wapl dosage partially corrects transcriptome phenotypes in Nipbl-/+ embryonic mouse brain
PRJNA838015 | ENA
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