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MetabolomicsComparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach

The human gut microbiome establishes and matures during infancy, and dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members to investigate the early development of the gut microbiota. Fecal samples from 20...

2024-03-07 | MTBLS7670 | MetaboLights
MetabolomicsComparative metabolomic responses to gibberellic acid and 6-benzylaminopurine in Cunila menthoides Benth. (Lamiaceae): a contribution to understand the metabolic pathways
Little is known about the effects of 6-benzylaminopurine (BA) and gibberellic acid (GA3) on the synthesis of secondary metabolites in species of Lamiaceae. In this study, for the first time, the profile of secondary metabolites in plantlets of Cunila menthoides was characterized, using UPLC-ESI-Qq-o...
2018-05-24 | MTBLS581 | MetaboLights
GenomicsChIP-seq of tumour associated macrophages derived from high grade ovarian serous carcinoma patient ascites
Tumor associated macrophages of one patient were assayed for histone modifications, methylation (MIRA) and CEBP.
ORGANISM(S): Homo sapiens 
2018-08-13 | E-MTAB-6297 | biostudies-arrayexpress
TranscriptomicsAltered glycogen metabolism causes hepatomegaly following an Atg7 deletion
Autophagy is a lysosomal degradation process involved in the turnover of organelles or other cell constituents, in providing sources for energy production under starving conditions, and in cell metabolism. A key protein in the macroautophagic machinery is the autophagy related protein (Atg) 7. Const...
ORGANISM(S): Mus musculus 
2016-07-12 | E-MTAB-4389 | biostudies-arrayexpress
MetabolomicsIdentification of pre-diagnostic lipid sets associated with liver cancer risk using untargeted lipidomics and chemical set analysis – a nested case-control study within the ATBC cohort

In pre-disposed individuals, a reprogramming of the hepatic lipid metabolism may support liver cancer initiation. We conducted a high-resolution mass spectrometry based untargeted lipidomics analysis of pre-diagnostic serum samples from a nested case-control study (219 liver cancer cases and 219 ...

2023-09-18 | MTBLS7776 | MetaboLights
TranscriptomicsRNA-seq of murine CD4 T cells after pentanoate treatment compared to untreated control
To analyse the influence of pentanoate on the differentiation of naive CD4 T cells under Th17 inducing conditions, murine CD4 T cells were isolated from spleen and lymphnodes of FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice). The T cells were kept for 3 days under Th17 inducing condition...
ORGANISM(S): Mus musculus 
2019-01-15 | E-MTAB-6114 | biostudies-arrayexpress
TranscriptomicsRNA-seq of murine spleen B-cells after pentanoate treatment compared to untreated control
We tested the influence of pentanoate on B cells by treatment of CpG-stimulated B cells in vitro. We isolated naive B cells from FIR/TIGER mice (IL-10 (GFP) - Foxp3 (RFP) - Reporter mice) from spleen. Cells were cultured in presence of 5 µg/ml CpG 2395. 24h after CpG-stimulation, B cells were treate...
ORGANISM(S): Mus musculus 
2019-01-15 | E-MTAB-6115 | biostudies-arrayexpress
TranscriptomicsThe transcriptional signature of ascites-associated macrophages is linked to interferon signaling and a favorable clinical outcome in a subgroup of ovarian carcinoma patients
mRNA from tumor associated macrophages from high grade serous ovarian carcinoma patients was sequenced.
ORGANISM(S): Homo sapiens 
2017-02-01 | E-MTAB-5199 | biostudies-arrayexpress
GenomicsSP1/2/3 and NfY cooccurency in MEFs
Investigation of the binding behaviour of Sp1, Sp2, Sp3 and NF-ya, NF-yb and NF-yc in mouse embryonic fibroblasts and of Sp1, Sp2 and Sp3 in HEK-293 cells reveals distinct binding of the seemingly similar transcription factors Sp1/3 and Sp2.
ORGANISM(S): Mus musculus 
2015-01-30 | E-MTAB-2970 | biostudies-arrayexpress
TranscriptomicsElevated expression of the H3K36me2 demethylase Kdm8/Jmjd5, a direct Miz1 target gene causes prolonged postnatal Schwann cell proliferation in the murine Miz1∆POZ neuropathy
The deletion of the POZ domain of the transcription factor Miz1 leads to a late onset neuropathy with subsequent spontaneous regeneration in mice. In this study, we aim to identify genes that are involved in the development of this neuropathy. We traced first gene regulatory changes in sciatic nerve...
ORGANISM(S): Mus musculus 
2018-03-14 | E-MTAB-5600 | biostudies-arrayexpress
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