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ProteomicsQuick and clean: Cracking E.coli’s code by LC-MS/MS, de novo sequencing, and dictionary search
In this study, we faced the challenge of deciphering a protein that has been designed and expressed by E.coli in such a way that the amino acid sequence encodes two concatenated English sentences. The sequence carried unknown modifications and cannot be found online. The letters ‘O’ and ‘U’ are both...
ORGANISM(S): Escherichia coli 
2020-05-26 | PXD012015 | Pride
Proteomics E.coli De novo sequencing 
ProteomicsDynamic human liver proteome atlas reveals functional insights into disease pathways
Deeper understanding of liver pathophysiology would benefit from a comprehensive quantitative proteome resource at cell-type resolution. Here, we quantify more than 10,000 proteins and 150,000 sequence-unique peptides across total liver, the major liver cell types, time-course of primary cell cultur...
ORGANISM(S): Homo sapiens (Human) 
2022-05-08 | PXD027722 | Pride
Human Atlas Primary cell culture Liver Liver disease Cirrhosis Nash 
ProteomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins, its diseases should affect the plasma proteome. Plasma Proteome Profiling of 48 patients with cirrhosis ...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-05 | PXD012056 | Pride
Mass spectrometry Biomarker discovery Plasma proteome profiling Nafld Nash 
ProteomicsHepatocyte-specific knockout of Nicotinamide phosphoribosyltransferase increases susceptibility for liver fibrosis in mice
We investigated the plasma and liver proteome changes in liver fibrosis in mice induced by hepatocyte-specific knockout of nicotinamide phosphoribosyltransferase (Nampt) upon a low-methionine, choline-free 60% high-fat (MCD) diet at multiple time points. We also investigated whether supplementation ...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-04 | PXD017170 | Pride
Dia Liver Plasma Fibrosis Nampt 
ProteomicsSpatially and cell-type resolved quantitative proteomic atlas of healthy human skin
Human skin provides both physical integrity and immunological protection from the external environment, using functionally distinct layers, cell types and extracellular matrix. Despite its central role in human health and disease, the constituent proteins of skin have not been systematically charact...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-10-15 | MSV000088236 | MassIVE
ProteomicsA novel hybrid high speed mass spectrometer allows rapid translation from biomarker candidates to targeted clinical tests using 15N labeled proteins
Recent developments in affinity binder or mass spectrometry (MS)-based plasma proteomics are now producing panels of potential biomarker candidates for diagnosis or prognosis. However, clinical validation and implementation of these biomarkers remain limited by the reliance on dated triple quadrupol...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-17 | MSV000095051 | MassIVE
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins its diseases should affect the plasma proteome. Plasma proteome profiling on 48 patients with cirrhosis o...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084333 | MassIVE
Proteomics,MultiomicsPlasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis, where treatment options are limited. As the liver secrets most of the blood plasma proteins, its diseases should affect the plasma proteome. Plasma Proteome Profiling of 48 patients with cirrhosis ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000084332 | MassIVE
ProteomicsPlasma proteome profiling reveals global and specific changes of inflammatory and lipid homeostasis markers after bariatric surgery
Obesity-related diseases now affect half of the global population, and bariatric surgery is one of the few interventions with long lasting weight loss and cardio-metabolic effects. Here, we investigated the effect of Roux-en-Y gastric bypass surgery on the plasma proteome, hypothesizing that specifi...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-09-19 | MSV000084344 | MassIVE
ProteomicsNovel Peptidomic Analysis Identifies Peptide Clusters with Potential for Disease Diagnosis and Dysregulated Proteolytic Processing
Mass spectrometry-based peptidomics provides a comprehensive approach to delineate the global proteolytic landscape of diseases and to identify potential biomarkers. However, current data analysis methods struggle to distill the peptidomic signatures of diseases. In this study, we conducted a peptid...
ORGANISM(S): Homo Sapiens 
2025-04-02 | PXD062496 |
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