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ProteomicsProteomics reveals the function reverse of MPSSS treated prostate cancer-associated fibroblasts to suppress PC-3 cell viability via the FoxO pathway
Prostate cancer (PCa) remains the malignancy with the highest morbidity in men (1). Although early-stage PCa usually causes no symptoms, cancer cells in prostate glands readily metastasize to bones, lymph nodes, lungs, and liver during PCa progression (2). Common strategies, including surgery, radia...
ORGANISM(S): Homo sapiens (Human) 
2021-03-22 | PXD023689 | Pride
Human Proteomics Prostate cafs Secretomics Prostate cancer cells Lc-ms/ms 
MetabolomicsTidal filtering drives microbiome assembly and metabolic coupling in desiccation-tolerant red algae


This study investigates how the intertidal red alga Pyropia haitanensis (Bangiophyceae) achieves rapid desiccation-rehydration tolerance through coordinated interactions between the host, its associated microbiome, and key metabolites. By integrating 16S rRNA amplicon sequencing, metag...

2026-05-07 | MTBLS13613 | MetaboLights
MetabolomicsExercise Activates Interferon Immune Response of the Liver via Gpld1 to Enhance Antiviral Innate Immunity

Healthy behavioral patterns could modulate organ functions to enhance the body’s immunity. However, whether exercise regulates antiviral innate immunity remains elusive. Here, we found that exercise promotes type-I IFN (IFN-I) production in the liver and enhances IFN-I immune activity of the body...

2024-04-24 | MTBLS7972 | MetaboLights
ProteomicsLRRC71 is essential for sperm motility, fertilization and male fertility
Although sperm supply half the genomic material necessary for generating viable offspring in sexual reproduction, the core molecular mechanisms underlying their formation remain largely unelucidated. Here, we demonstrate that leucine-rich repeat-containing 71 (LRRC71) is essential for spermatogenesi...
ORGANISM(S): Mus Musculus 
2026-04-29 | PXD077837 |
ProteomicsPlasma proteome profiling combined with clinical and genetic features reveals pathophysiological characteristics of β-thalassemia
The phenotype of β-thalassemia underlies multigene interactions, making clinical stratification complicated. An increasing number of genetic modifiers affecting the disease severity have been identified, but are still unable to meet the demand of precision diagnosis. Here, we systematically conducte...
ORGANISM(S): Homo Sapiens 
2022-03-10 | PXD032179 |
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