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TranscriptomicsTranscription profiling of human brain Total RNA vs Universal Human Reference RNA on 4 different commercially available microarrays
Commercially available human genomic microarrays from four different manufacturers were used to compare Human Brain Total RNA against Universal Human Reference RNA (both commercially available) prepared at two different starting amounts (20 µg or 1µg). For each amount of RNA, 6 replicates were perfo...
ORGANISM(S): Homo sapiens 
2011-11-08 | E-LGCL-5 | biostudies-arrayexpress
TranscriptomicsTranscriptomic output of endogenous KRasG12D and modestly overexpressed MYC in MEFs
We sought to compare the transcriptomic output of Kras activation with that of modestly overexpressed cMYC, to better understand the mechanism of oncogenic cooperation. We isolated fibrobalsts from mouse embryos carrying CRE-inducible alleles for KRasG12D (LSL-KRasG12D) and MYC (Rosa26-LSL-MYC), al...
ORGANISM(S): Mus musculus 
2020-03-16 | E-MTAB-6824 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human brain total RNA vs Universal Human Reference RNA on 4 different commercially available microarrays
Commercially available human genomic microarrays from four different manufacturers were used to compare Human Brain Total RNA against Universal Human Reference RNA (both commercially available) prepared at two different starting amounts (20 µg or 1µg). For each level of RNA, 6 replicates were perfor...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-LGCL-2 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human brain total RNA vs Universal Human Reference RNA on 4 different commercially available microarrays
Commercially available human genomic microarrays from four different manufacturers were used to compare Human Brain Total RNA against Universal Human Reference RNA (both commercially available) prepared at two different starting amounts (20 µg or 1µg). For each level of RNA, 6 replicates were perfor...
ORGANISM(S): Homo sapiens 
2004-04-01 | E-LGCL-4 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human brain total rna against universal human reference rna (both commercially available) prepared at two different starting amounts (20 ug or 1ug
Commercially available human genomic microarrays from four different manufacturers were used to compare Human Brain Total RNA against Universal Human Reference RNA (both commercially available) prepared at two different starting amounts (20 µg or 1µg). For each level of RNA, 6 replicates were perfor...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-LGCL-3 | biostudies-arrayexpress
TranscriptomicsProgression of KRas^G12D;Rosa26-MYC tumours to invasive disease
The aim of the study was to investigate gene expression tumour progression of KRas*/MYC driven lung tumours from adenocarcinoma in situ to invasive disease.
ORGANISM(S): Mus musculus 
2018-06-01 | E-MTAB-6432 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant A549 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6483 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H2009 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6486 | biostudies-arrayexpress
TranscriptomicsRNA-seq to investigate impact of treatment of KRAS mutant NCI-H358 lung adenocarcinoma cells with the multi-ERBB inhibitor Neratinib
KRAS mutation is widely presumed to confer independence from upstream RTK signalling, however emerging evidence from mouse models of lung cancer suggests that ERBB RTKs may amplify signalling through RAS isoforms and participate in mutant RAS-driven lung cancer. This is one of 3 datasets where we e...
ORGANISM(S): Homo sapiens 
2018-06-01 | E-MTAB-6485 | biostudies-arrayexpress
TranscriptomicsIn situ depletion of Nuak1 in murine colon tumours
The aim of the project is to determine the impact of NUAK1 depletion on the transcriptome of in situ colon tumours. Tumours were initiated in Villin-CRE-ER;APC-floxed;DI-shNUAK1 mice, followed by treatment for 1 week with dextran sodium sulphate. 68 days after tumour initiation, NUAK1 shRNAs were ...
ORGANISM(S): Mus musculus 
2018-02-19 | E-MTAB-6265 | biostudies-arrayexpress
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