Sort   by:  
 Page size 
ProteomicsNKX2-1 IP-MS on RPMI-8402 NKX2-1 +/+ and -/-
Unravel the binding partners of NKX2-1 transcription factor in RPMI-8402 NKX2-1 +/+, using NKX2-1 -/- as negative control.
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD057622 | Pride
Human Nkx2-1 Leukemia 
GenomicsNkx2-1 Represses a Latent Gastric Differentiation Program in Lung Adenocarcinoma
Tissue-specific differentiation programs become dysregulated during cancer evolution. The transcription factor Nkx2-1 is a master regulator of pulmonary differentiation that is downregulated in poorly differentiated lung adenocarcinoma. Here we use conditional murine genetics to study the fate of l...
ORGANISM(S): Mus musculus 
2013-04-09 | E-GEOD-43252 | biostudies-arrayexpress
ProteomicsRUNX1 IP-MS on RPMI-8402 NKX2-1 +/+ and -/-
Unravel the binding partners of RUNX1 transcription factor in RPMI-8402 NKX2-1 +/+ and NKX2-1 -/-.
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD057654 | Pride
Human Nkx2-1 Runx1 Leukemia 
TranscriptomicsSuppression of Lung Adenocarcinoma Progression by Nkx2-1
Despite the high prevalence and poor outcome of patients with metastatic lung cancer, the mechanisms of tumour progression and metastasis remain largely uncharacterized. We modelled human lung adenocarcinoma, which frequently harbours activating point mutations in KRAS1 and inactivation of the p53-p...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-26874 | biostudies-arrayexpress
TranscriptomicsThe homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells (microRNA)
Cell-specific gene expression is achieved by a combination of mechanisms including transcriptional and post-transcriptional regulation. The transcription factor Nkx2-1, essential for lung cell differentiation, mainly acts in transcriptional activation but can directly or indirectly repress gene expr...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-47053 | biostudies-arrayexpress
TranscriptomicsThe homeobox transcription factor Nkx2-1 regulates microRNAs controlling downstream gene silencing in lung epithelial cells (mRNA)
Cell-specific gene expression is achieved by a combination of mechanisms including transcriptional and post-transcriptional regulation. The transcription factor Nkx2-1, essential for lung cell differentiation, mainly acts in transcriptional activation but can directly or indirectly repress gene expr...
ORGANISM(S): Mus musculus 
2015-12-22 | E-GEOD-47054 | biostudies-arrayexpress
GenomicsNKX2-1 occupancy in human lung adenocarcinoma cell lines
The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To better understand how genomic alterations of NKX2-1 drive tumorigenesis, we generated an expression signature associated with NKX2-1 amplification in hum...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-39998 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression by NKX2-1 suppression in NCI-H2009 cells
The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To better understand how genomic alterations of NKX2-1 drive tumorigenesis, we generated an expression signature associated with NKX2-1 amplification in hum...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-GEOD-40270 | biostudies-arrayexpress
GenomicsSmad3, Smad4 and TTF-1/NKX2-1 binding sites in H441/A549 lung cancer cell lines
We evaluated the role of TTF-1/NKX2-1 on Smad3 and Smad4 binding in lung cancer cell lines. Smad3 binding sites in A549 cells and Smad3, Smad4, and TTF-1/NKX2-1 binding sites in H441 cells were determined by ChIP-seq.
ORGANISM(S): Homo sapiens 
2014-07-27 | E-GEOD-51509 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human bronchial epithelial cells overexpressing the lung developmental transcription factors TTF1, NKX2-8 and PAX9
We investigated the clinical implications of lung developmental transcription factors (TTF-1, NKX2-8, and PAX9) which we recently discovered as cooperating oncogenes activated by way of gene amplification at chromosome 14q13 in lung cancer. Using stable transfectants of human bronchial epithelial ce...
ORGANISM(S): Homo sapiens 
2009-04-10 | E-GEOD-9212 | biostudies-arrayexpress
Sort   by:  
 Page size