Sort   by:  
 Page size 
TranscriptomicsGene expression data from wild-type and Nlrc5 knockout GM-CSF induced bone marrow dendritic cells infected with Newcastle Disease virus.
Nlrc5 is encoding a Nod-like receptor protein NLRC5/NOD27. To check the involvement of Nlrc5 in antiviral response, we examined gene expression profile in wild-type and Nlrc5 knockout GM-CSF bone marrow macrophage with using microarrays. Bone marrow cells were cultured with GM-CSF and harvested on d...
ORGANISM(S): Mus musculus 
2010-12-22 | E-GEOD-22448 | biostudies-arrayexpress
GenomicsNLRC5 specifically transactivates MHC class I and related genes through a distinctive SXY module
MHC class II (MHCII) genes are transactivated by the NOD-like receptor (NLR) factor CIITA, which is recruited to SXY regulatory modules of MHC promoters via a DNA-binding “enhanceosome” complex. NLRC5, another NLR protein, was recently found to control transcription of MHC class I (MHCI) genes. Howe...
ORGANISM(S): Mus musculus 
2015-02-27 | E-GEOD-59092 | biostudies-arrayexpress
TranscriptomicsNLRC5 is a transcriptional regulator of MHC class I genes
NLRC5 is a member of the NLR family of proteins. The observation that NLRC5 is found in the nucleus prompted us to perform a gene array to identify putative target genes of NLRC5. We generated Jurkat T cell lines that stably express either the wild-type or mutant forms of NLRC5 harboring mutations i...
ORGANISM(S): Homo sapiens 
2010-07-30 | E-GEOD-22064 | biostudies-arrayexpress
ProteomicsNLRC5 IP-MS in neonatal mouse cardiomyocyte lysates
The neonatal mouse cardiomyocytes (NMCMs) lysate was immunoprecipitated using either IgG (control) or anti-NLRC5 antibody. Immunoprecipitated samples were subjected to SDS-PAGE followed by high-throughput LC/MS to identify the candidate interacting proteins of NLRC5.
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051371 | Pride
Immunoprecipitation Nlrc5 Mass spectrometry 
ProteomicsEssential role of NLRC5 in cancer immune surveillance and cancer immunoediting
Background/Objectives: Downregulation of NLRC5, the transcriptional activator of MHC class-I, results in tumor immune evasion via escape from CD8+ T cell-mediated tumor control. As NLRC5 deficiency does not abrogate CD8+ T cell development, we investigated whether NLRC5-dependent antitumor immune me...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-19 | PXD060523 | Pride
Cancer immune surveillance  cancer immunoediting  nlrc5  mhc class-i  3-methylcholanthrene  cytolytic t lymphocyte  granzyme 
GenomicsNLRC5 KO murine study
The role of NLRC5 knock out in high fat diet-induced obesity measured in female mice after 11-weeks of intervention
PRJEB57871 | ENA
GenomicsNLRC5 deficiency protects against acute kidney injury in mice by mediating CEACAM1 signaling
NLRC5 deficiency protects against acute kidney injury in mice by mediating CEACAM1 signaling
PRJNA430704 | ENA
GenomicsThe subcellular redistribution of NLRC5 promotes angiogenesis via interacting with STAT3 in endothelial cells
The subcellular redistribution of NLRC5 promotes angiogenesis via interacting with STAT3 in endothelial cells
PRJNA668707 | ENA
UnknownNLRC5, at the Heart of Antigen Presentation.
Not available
S-EPMC3837245 | biostudies-literature
GenomicsTargeted demethylation and activation of NLRC5 augments cancer immunogenicity through MHC class I
Targeted demethylation and activation of NLRC5 augments cancer immunogenicity through MHC class I
PRJNA975212 | ENA
Sort   by:  
 Page size