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ProteomicsAn Nlrp5-null mutation leads to attenuated de novo methylation in oocytes, accompanied by significant reduction in DNMT3L
Nlrp5 encodes a core component of the subcortical maternal complex (SCMC) a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embryo arrest, recurrent molar pregnancies and imprinting disorde...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-22 | PXD056859 | Pride
Nlrp5 Subcortical maternal complex Oocyte Dna methylation 
GenomicsTranscriptional profiling of Nlrp5 +/+, -/- and +/- germinal vesical murine oocytes
Transcriptional profiling of Nlrp5 +/+, -/- and +/- germinal vesical murine oocytes
PRJNA1165734 | ENA
GenomicsDNA methylation profiling of Nlrp5 +/+, and -/- and germinal vesical murine oocytes
DNA methylation profiling of Nlrp5 +/+, and -/- and germinal vesical murine oocytes
PRJNA1165732 | ENA
TranscriptomicsTranscriptional profiling of Nlrp5 +/+, -/- and +/- germinal vesical murine oocytes
Nlrp5 encodes a core component of the subcortical maternal complex (SCMC) a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embryo arrest, recurrent molar pregnancies and imprinting disorde...
ORGANISM(S): Mus musculus 
2025-12-30 | GSE278124 | GEO
Methylation profilingDNA methylation profiling of Nlrp5 +/+, and -/- and germinal vesical murine oocytes
Nlrp5 encodes a core component of the subcortical maternal complex (SCMC) a cytoplasmic protein structure unique to the mammalian oocyte and cleavage-stage embryo. NLRP5 mutations have been identified in patients presenting with early embryo arrest, recurrent molar pregnancies and imprinting disorde...
ORGANISM(S): Mus musculus 
2025-12-30 | GSE278123 | GEO
UnknownMutations in NLRP5 and NLRP9 are Associated with Litter Size in Small Tail Han Sheep.
Not available
S-EPMC7222816 | biostudies-literature
UnknownMutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.
Not available
S-EPMC4568303 | biostudies-literature
UnknownThe maternal protein NLRP5 stabilizes UHRF1 in the cytoplasm: implication for the pathogenesis of multilocus imprinting disturbance.
Not available
S-EPMC11373322 | biostudies-literature
UnknownMutations in OOEP and NLRP5 identified in infertile patients with early embryonic arrest.
Not available
S-EPMC10087254 | biostudies-literature
UnknownNovel mutations in NLRP5 and PATL2 cause female infertility characterized by primarily oocyte maturation abnormality and consequent early embryonic arrest.
Not available
S-EPMC8995404 | biostudies-literature
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