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ProteomicsInhibition of spinal cord Hsp90 enhances morphine anti-nociception by activating an ERK/RSK pathway
Morphine and other opioids continue to be commonly utilized as clinical analgesics, despite their numerous adverse side effects, including respiratory depression, addiction, and tolerance. The modulation of µ-opioid receptor (MOR) signaling and subsequent behavioral output is one viable approach to ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-24 | PXD015060 | Pride
Hsp90 Anti-nociception Erk Spinal cord 
TranscriptomicsEyeless: Pitx3 mutant mouse line, Expression profiling of liver
A new mouse mutant arose spontaneously at the 5th inbred generation in a congenic C3H/He line. Since the mice suffered from anophthalmia or microphthalmia, we referred to this new mutant as eyeless (provisional gene symbol: eyl). The mutation follows an autosomal recessive pattern of inheritance and...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-15336 | biostudies-arrayexpress
ProteomicsAntagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Anti-Nociception by Activating Src and CaMKII Signaling
The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for the MDOR in vivo is indirect and limited,...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD022106 | Pride
Opiod mdor oxymorphone nociception 
GenomicsC57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception
C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception
PRJNA490131 | ENA
Genomics
Toxoplasmosis and colon nociception
PRJNA1224722 | ENA
TranscriptomicsTranscription profiling of dicer knock-out nociceptive sensory neurons from mice to investigate the roles of microRNAs in nociception
We used the Nav1.8-Cre to delete Dicer in mouse nociceptive sensory neurons to investigate the roles of microRNAs in nociception.
ORGANISM(S): Mus musculus 
2010-01-01 | E-MEXP-1461 | biostudies-arrayexpress
UnknownMonitoring surgical nociception using multisensor physiological models.
Not available
S-EPMC11459174 | biostudies-literature
UnknownTrpA1 regulates thermal nociception in Drosophila.
Not available
S-EPMC3164203 | biostudies-literature
UnknownNociceptor-Enriched Genes Required for Normal Thermal Nociception.
Not available
S-EPMC5333372 | biostudies-literature
UnknownAn assay for chemical nociception in Drosophila larvae.
Not available
S-EPMC6790381 | biostudies-literature
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