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ProteomicsInhibition of spinal cord Hsp90 enhances morphine anti-nociception by activating an ERK/RSK pathway
Morphine and other opioids continue to be commonly utilized as clinical analgesics, despite their numerous adverse side effects, including respiratory depression, addiction, and tolerance. The modulation of µ-opioid receptor (MOR) signaling and subsequent behavioral output is one viable approach to ...
ORGANISM(S): Mus musculus (Mouse) 
2020-04-24 | PXD015060 | Pride
Hsp90 Anti-nociception Erk Spinal cord 
UnknownDevelopment, Validation, and Comparison of a Novel Nociception/Anti-Nociception Monitor against Two Commercial Monitors in General Anesthesia.
Not available
S-EPMC11013864 | biostudies-literature
ProteomicsAntagonism of the Mu-Delta Opioid Receptor Heterodimer Enhances Opioid Anti-Nociception by Activating Src and CaMKII Signaling
The opioid receptors are important regulators of pain, reward, and addiction. Limited evidence suggests the mu and delta opioid receptors form a heterodimer (MDOR), which may act as a negative feedback brake on opioid-induced analgesia. However, evidence for the MDOR in vivo is indirect and limited,...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD022106 | Pride
Opiod mdor oxymorphone nociception 
UnknownCRMP-2 peptide mediated decrease of high and low voltage-activated calcium channels, attenuation of nociceptor excitability, and anti-nociception in a model of AIDS therapy-induced painful peripheral neuropathy.
Not available
S-EPMC3502107 | biostudies-literature
UnknownResolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception.
Not available
S-EPMC2990166 | biostudies-literature
UnknownEnhanced Anti-Nociception by Novel Dual Antagonists for 5-HT2AR and mGluR5 in Preclinical Models of Pain.
Not available
S-EPMC12564658 | biostudies-literature
TranscriptomicsModulation of Inflammatory Pain by Myeloid FABP5
The initiation and maintenance of pain involves complex neuroimmune interactions, with myeloid cell output finetuning the balance between pronociceptive and antinociceptive signaling. Fatty acid binding protein 5 (FABP5) is a lipid chaperone whose inhibition produces antinociceptive effects in model...
ORGANISM(S): Mus musculus 
2025-11-07 | GSE298388 | GEO
UnknownTargeting Anti-Inflammatory Pathways to Treat Diabetes-Induced Neuropathy by 6-Hydroxyflavanone.
Not available
S-EPMC10255489 | biostudies-literature
UnknownThe respiratory depressant effects of mitragynine are limited by its conversion to 7-OH mitragynine.
Not available
S-EPMC9314834 | biostudies-literature
UnknownDiosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain.
Not available
S-EPMC9784430 | biostudies-literature
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