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In this project we aimed to investigate the effect of Goreisan (GRS, traditional herbal medicine) on HFpEF model heart failure mouse. HFpEF was induced by administration of high-fat diet (HFD)and N-nitro-L-arginine methyl ester (L-NAME), with or without GRS. Mouse heart proteome was analyzed with LC...
ORGANISM(S): Mus Musculus (mouse) 
CRISPR-Cas9 has tremendous potential as a therapeutic tool for treating human diseases. However, prolonged expression of the nuclease and gRNA from viral vectors in an in vivo context may cause off-target activity and immunogenicity. While extracellular vesicles have been recently demonstrated to be...
ORGANISM(S): Homo Sapiens (human) 
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