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TranscriptomicsComparative transcription profiling of peripheral blood mononuclear cells from vasculitis patients
Peripheral blood mononuclear cells (PBMCs) from 13 vasculitis patients expressed varying gene profiles. A total of 13 sets of two color arrays were performed and each individual array included a target sample and a control sample.
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-16945 | biostudies-arrayexpress
TranscriptomicsFicolin-1 is upregulated in leukocytes and glomeruli from microscopic polyangiitis patients
To search for new markers of active lesions that might help better understand the molecular basis of MPA and aid in its diagnosis, DNA microarray analysis was performed with peripheral blood mononuclear cells (PBMCs). A total of 12 sets of two color arrays were performed and each individual array in...
ORGANISM(S): Homo sapiens 
2013-08-18 | E-GEOD-41744 | biostudies-arrayexpress
TranscriptomicsDNA microarray analysis of PBMCs from Behçet’s disease (BD) patients
To examine if gene expression profiles of many Behçet’s disease (BD) patients are commonly abnormal compared to those of healthy volunteers, we performed a genome-wide complementary DNA microarray analysis using an Agilent Hu44K array; RNA samples were isolated from the PBMCs of 41 individual BD ...
ORGANISM(S): Homo sapiens 
2016-01-21 | E-GEOD-70403 | biostudies-arrayexpress
TranscriptomicsGene expression in mouse leukocytes after CAWS administration
We performed DNA microarray analyses and compared the difference in the transcriptome between B6 and DBA/2 mice with modest or dramatic sensitivity to CAWS-vasculitis, respectively. Candida albicans water-soluble fraction (CAWS), a mannoprotein-M-NM-2-glucan complex obtained from the culture superna...
ORGANISM(S): Mus musculus 
2013-09-30 | E-GEOD-44803 | biostudies-arrayexpress
TranscriptomicsmiRNA array analysis following gefinitib/luteolin administration to PC-3 cells
To determine if any altered miRNA expression is actually involved in the growth inhibition and/or cell death induction by luteolin and/or gefitinib, we performed miR-array analysis using RNA from PC-3 cells after 24h of treatment with 60μM luteolin and/or 60μM gefitinib. PC-3 cells were treated fo...
ORGANISM(S): Homo sapiens 
2014-06-29 | E-GEOD-53178 | biostudies-arrayexpress
TranscriptomicsExpression profiling in primary embryonic fibroblasts deficient for the N-terminal truncation of Lats1
Lats1 and Lats2 are the mediators of the Hippo pathway that regulates tissue growth and proliferation. Lats1 and Lats2 kinases share 85% sequence identity in the kinase domain. However, their non-kinase regions at the N-terminus are distinct except for Lats conserved domain 1 (LCD1) and LCD2, sugges...
ORGANISM(S): Mus musculus 
2012-12-17 | E-GEOD-37871 | biostudies-arrayexpress
TranscriptomicsWithaferin A (WA) causes cell death in prostate cells.
Withaferin A (WA), a major chemical component of an Indian herb Withania somnifera, induces cell death (apoptosis/necrosis) in a variety of tumor cells, but its molecular mechanism remains elusive. We report that WA induces cell death selectively in high-grade prostate (PC-3 and DU-145) and tongue (...
ORGANISM(S): Homo sapiens 
2015-08-02 | E-GEOD-55728 | biostudies-arrayexpress
TranscriptomicsNucleoredoxin is required for the maintenance of Wnt/β-catenin signaling in mice embryo
We previously showed that nucleoredoxin (NRX) suppresses Wnt/β-catenin signaling through its binding to Dishevelled (Dvl) (Nat Cell Biol 8, 501-508 (2006)). To clarify the in vivo role of NRX in mammals, we here generate NRX gene-knockout mice (NRX-/- mice) by homologous recombination. NRX-/- mice ...
ORGANISM(S): Mus musculus 
2010-10-26 | E-GEOD-21954 | biostudies-arrayexpress
TranscriptomicsFocused transcription profiling of peripheral blood mononuclear cells from vasculitis patients
Peripheral blood mononuclear cells (PBMCs) from 13 vasculitis patients expressed varying gene profiles. A total of 14 sets of one color arrays were performed. Four technical replicates were performed for each sample.
ORGANISM(S): Homo sapiens 
2010-11-10 | E-GEOD-18247 | biostudies-arrayexpress
TranscriptomicsGene expression in the whole brains of two spontaneously hypertensive rat strains at 3 and 6 weeks of age
We examined gene expression profiles in the rat whole brains using genome-wide microarray technology, and determined gene expression profiles in 3 rat strains: normotensive WKY, spontaneously hypertensive rats (SHR), and stroke-prone SHR (SHRSP). To identify candidate genes involved in the genesis o...
ORGANISM(S): Rattus norvegicus 
2014-01-24 | E-GEOD-41452 | biostudies-arrayexpress
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