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MetabolomicsNon-canonical Metabolic and Molecular Effects of Calorie Restriction Are Revealed by Varying Temporal Conditions

Calorie restriction (CR) extends lifespan and healthspan in diverse species. However, comparing ad libitum (AL) and CR-fed mice is challenging due to their significantly different feeding patterns. CR-fed mice consume their daily meal in approximately 2 hours, subjecting themselves to a prol...

2025-07-07 | MTBLS10795 | MetaboLights
TranscriptomicsCanonical and non-canonical EcfG sigma factors control the general stress response in Rhizobium etli
A core component of the M-NM-1-proteobacterial general stress response is the extracytoplasmic function (ECF) sigma factor EcfG, exclusively present in this taxonomic class. Half of the completed M-NM-1-proteobacterial genome sequences contain two or more copies of genes encoding M-OM-^CEcfG-like si...
ORGANISM(S): Rhizobium etli CFN 42 
2013-12-20 | E-GEOD-53517 | biostudies-arrayexpress
ProteomicsWNT7 Promotes Proliferation of Pancreatic Progenitor Cells Differentiated from Human Pluripotent Stem Cells through Non-Canonical Wnt Signaling Pathway
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
2022-03-27 | PXD018222 | JPOST Repository
ProteomicsWNT7 Promotes Proliferation of Pancreatic Progenitor Cells Differentiated from Human Pluripotent Stem Cells through Non-Canonical Wnt Signaling Pathway
A small molecule, AT7867, promotes proliferation of human pluripotent stem cell-derived pancreatic progenitor cells (PPCs), yet detailed mechanisms of its proliferative effect were not fully understood. Here, we performed cell-based siRNA screening on a subset of genes to reveal that WNT7B is a grow...
ORGANISM(S): Homo Sapiens (human) 
2021-07-01 | PXD018221 | JPOST Repository
TranscriptomicsGene expression profiles of canonical and non-canonical NF-κB signaling pathways in Hodgkin’s lymphoma
Malignant Hodgkin's lymphoma (HL) cells are characterized by constitutive activation of the canonical as well as the non-canonical NF-κB signaling cascades. We depleted subunit combinations corresponding to either canonical (p50/RelA) or non-canonical (p52/RelB) dimers in the HL cell line L-1236 an...
ORGANISM(S): Homo sapiens 
2016-02-18 | E-GEOD-64232 | biostudies-arrayexpress
Proteomicsnon-canonical HLA peptides in cancer
Efforts to precisely identify tumor human leukocyte antigen presented peptides (HLAp) capable of mediating T cell based tumor rejection still face important challenges. Recent reports suggest that non-canonical cancer HLAp could be immunogenic but their identification requires highly sensitive and a...
ORGANISM(S): Homo sapiens (Human) 
2020-03-27 | PXD013649 | Pride
Non-canonical translation products Mass spectrometry Cancer immunotherapy Immunopeptidomics Antigen discovery 
ModelsTrares2022 - Non-canonical NF-kB pathway, Petri net
No description
2022-07-22 | MODEL2207210002 | BioModels
ModelsTrares2022 - Crosstalk between the canonical and non-canonical NF-kB pathways, Petri net
No description
2022-07-22 | MODEL2207210003 | BioModels
ProteomicsDiscovery of non-canonical translation initiation sites through mass spectrometric analysis of protein N-termini
Translation initiation generally occurs at AUG codons in eukaryotes although it has been shown that non-AUG or non-canonical translation initiation can also occur. However, the evidence for non-canonical translation initiation sites (TISs) is largely indirect and based on ribosome profiling studies....
ORGANISM(S): Homo sapiens (Human) 
2017-11-23 | PXD006633 | Pride
Human Non-canonical Tails 
GenomicsmtRF1 recognises non-canonical stop codons in human mitochondria
mtRF1 recognises non-canonical stop codons in human mitochondria
PRJNA896508 | ENA
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