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GenomicsTranslation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames. To address this question, we performed ribosome profiling of 32 medullob...
EGAS00001007426 | EGA
GenomicsThe Translation of Non-Canonical Open Reading Frames Controls Mucosal Immunity
The Translation of Non-Canonical Open Reading Frames Controls Mucosal Immunity
PRJNA494404 | ENA
ProteomicsTMT-based quantitative proteomic analysis of SAHA-treated human HeLa cells
We performed a TMT-based quantitative proteomic analysis of SAHA-perturbed human HeLa cells using advanced RTS platform on Orbitrap Eclipse Tribrid MS system.
ORGANISM(S): Homo Sapiens (human) 
2023-06-09 | PXD038681 | JPOST Repository
GenomicsPervasive functional translation of noncanonical open reading frames
Pervasive functional translation of noncanonical open reading frames
PRJNA544411 | ENA
ProteomicsPeptide analysis in human cell lines via high-resolution MRM (PRM) for the annotation of non-canonical open reading frames
A major scientific drive is to characterize the protein-coding genome, which is a primary basis for studying human health. But the fundamental question remains: what has been missed in prior analyses? Over the past decade, the translation of non-canonical open reading frames (ncORFs) has been obse...
ORGANISM(S): Homo sapiens (Human) 
2026-02-17 | PXD066599 | Pride
Cell lines Mrmhr (prm) Human Non-canonical open reading frames 
ProteomicsDiscovery of Non-Canonical Peptides Derived from Novel Small Open Reading Frames as MHC-I Epitopes
Immunopeptides that are translated in cells and presented at the cell surface by major histocompatibility complex (MHC) mole-cules are important epitopes in basic Immunology and translational cancer immunotherapy. While most of the reported immuno-peptides are derived from protein coding sequence, t...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD024415 | Pride
Price Ribotish Sorf Non-canonical peptides Lc-ms Mhc-i 
ProteomicsPervasive functional micropeptides in humans encoded by non-canonical open reading frames
Protein-coding regions of the genome continue to expand beyond canonical annotations and remain incompletely understood. Despite recent reports demonstrating important cellular functions played by micropeptides from unannotated open reading frames (ORFs), there exists no systematic method to fully u...
ORGANISM(S): Homo sapiens (Human) 
2020-03-06 | PXD014031 | Pride
Novel orfs Single cell rna analysis Crispr Ribosome sequencing Lcms 
GenomicsPMCDS000ABF - samples
This study aims to investigate the dysregulation of RNA translation and identify functional non-canonical open reading frames (ORFs) as potential targets for medulloblastoma treatment. The study involves ribosome profiling and RNAseq of medulloblastoma tissues and cell lines to observe the translati...
EGAD00001011192 | EGA
GenomicsPMCDS000ABG - samples
This study aims to investigate the dysregulation of RNA translation and identify functional non-canonical open reading frames (ORFs) as potential targets for medulloblastoma treatment. The study involves ribosome profiling and RNAseq of medulloblastoma tissues and cell lines to observe the translati...
EGAD00001011193 | EGA
UnknownOpenVar: functional annotation of variants in non-canonical open reading frames.
Not available
S-EPMC9375913 | biostudies-literature
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