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GenomicsTranslation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation. Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively oncogenic non-canonical open reading frames. To address this question, we performed ribosome profiling of 32 medullob...
EGAS00001007426 | EGA
ProteomicsIdentification of non-canonical translation products in C. elegans using tandem mass spectrometry
Identification of non-canonical translation products in C. elegans using tandem mass spectrometry using available orbitrap data and experiments on timsTOF Pro
ORGANISM(S): Caenorhabditis Elegans (ncbitaxon:6239) 
2021-07-29 | MSV000087909 | MassIVE
Proteomicsnon-canonical HLA peptides in cancer
Efforts to precisely identify tumor human leukocyte antigen presented peptides (HLAp) capable of mediating T cell based tumor rejection still face important challenges. Recent reports suggest that non-canonical cancer HLAp could be immunogenic but their identification requires highly sensitive and a...
ORGANISM(S): Homo sapiens (Human) 
2020-03-27 | PXD013649 | Pride
Non-canonical translation products Mass spectrometry Cancer immunotherapy Immunopeptidomics Antigen discovery 
ProteomicsDiscovery of non-canonical translation initiation sites through mass spectrometric analysis of protein N-termini
Translation initiation generally occurs at AUG codons in eukaryotes although it has been shown that non-AUG or non-canonical translation initiation can also occur. However, the evidence for non-canonical translation initiation sites (TISs) is largely indirect and based on ribosome profiling studies....
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-28 | MSV000098373 | MassIVE
UnknownIdentification of Non-Canonical Translation Products in C. elegans Using Tandem Mass Spectrometry.
Not available
S-EPMC8575065 | biostudies-literature
ProteomicsCheck of selected NTR peptide spectra by comparison with synthetic peptides
Ribosome profiling has revealed translation outside of canonical coding sequences (CDSs) including translation of short upstream ORFs, long non-coding RNAs, overlapping ORFs, ORFs in UTRs or ORFs in alternative reading frames. Studies combining mass spectrometry, ribosome profiling and CRISPR-based ...
ORGANISM(S): Homo Sapiens 
2022-08-02 | PXD030285 | panorama
ProteomicsDiversity in pervasive translation. A new translational landscape of yeast.
Pervasive translation is a widespread phenomenon that plays an important role in de novo gene birth; however, its underlying mechanisms remain unclear. Based on multiple Ribosome Profiling datasets, we investigated the translational landscape of coding and noncoding regions of yeast. Therefore, we d...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-09-04 | PXD040766 | Pride
Genome evolution Mass spectrometry Non-canonical translation signals De novo coding products Noncoding genome Pervasive translation 
ProteomicsLoss of function cancer associated mutations in the EIF4G2 non canonical translation initiation factor
Tumor cells often exploit the protein translation machinery, resulting in enhanced protein expression essential for tumor growth. Since canonical translation initiation is often suppressed due to cell stress in the tumor microenvironment, non-canonical translation initiation mechanisms become partic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-21 | MSV000092704 | MassIVE
GenomicsPMCDS000ABF - samples
This study aims to investigate the dysregulation of RNA translation and identify functional non-canonical open reading frames (ORFs) as potential targets for medulloblastoma treatment. The study involves ribosome profiling and RNAseq of medulloblastoma tissues and cell lines to observe the translati...
EGAD00001011192 | EGA
GenomicsPMCDS000ABG - samples
This study aims to investigate the dysregulation of RNA translation and identify functional non-canonical open reading frames (ORFs) as potential targets for medulloblastoma treatment. The study involves ribosome profiling and RNAseq of medulloblastoma tissues and cell lines to observe the translati...
EGAD00001011193 | EGA
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