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ProteomicsDeciphering the interaction between TopBP1 and GINS using crosslinking mass spectrometry
Recombinant TopBP1 and GINS were cross linked using the MS non-cleavable crosslinker BS3. Crosslinked proteins were then subsequently either digested directly using the SP3 strategy or first seperated on SDS-PAGE and then in-gel digested. cross-linked peptides were identified by LC-MS. The informati...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD040156 | Pride
Cross linking Gins Topbp1 Bs3 
ProteomicsIn Situ Structural Restraints from Crosslinking Mass Spectrometry in Human Mitochondria
The field of structural biology is increasingly focusing on studying proteins in situ, i.e. in a larger biological context. Crosslinking mass spectrometry is contributing to this effort, typically through the use of MS-cleavable crosslinkers. Here, we apply the popular non-cleavable crosslinker disu...
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD014675 | Pride
Crosslinking mass spectrometry Human mitochondria In situ large-scale structural biology Non-cleavable dss crosslinker Comparative modelling 
ProteomicsComparison of MS Annika 3.0 against other crosslink search engines
The field of crosslinking mass spectrometry has seen substantial advancements over the past decades, enabling the structural analysis of proteins and protein-complexes and serving as a powerful tool in protein-protein interaction studies. However, data analysis of large non-cleavable crosslink studi...
ORGANISM(S): Streptoccous pyogenes Escherichia coli 
2024-12-19 | PXD055512 | Pride
Non-cleavable Dss Adh Crosslinker Crosslinking 
ProteomicsFinding and using Diagnostic Ions in Collisional Induced Crosslinked Peptide Fragmentation Spectra
Crosslinking mass spectrometry (XL-MS) has emerged as a powerful tool in its own right for the investigation of protein structures and interactions. Utilizing standard shotgun MS mass spectrometry equipment and specialized database search software, crosslinked peptide-pairs can be identified and dir...
ORGANISM(S): Bos taurus (Bovine) 
2019-07-16 | PXD013083 | Pride
Xlinkx Crosslinking mass spectrometry Gas phase fragmentation of crosslinks 
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