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ProteomicsDeciphering the interaction between TopBP1 and GINS using crosslinking mass spectrometry
Recombinant TopBP1 and GINS were cross linked using the MS non-cleavable crosslinker BS3. Crosslinked proteins were then subsequently either digested directly using the SP3 strategy or first seperated on SDS-PAGE and then in-gel digested. cross-linked peptides were identified by LC-MS. The informati...
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD040156 | Pride
Cross linking Gins Topbp1 Bs3 
ProteomicsDNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans
Assembly of the DNA helicase known as CMG (CDC45-MCM-GINS) is the key regulated step during DNA replication initiation in eukaryotes. Using the Caenorhabditis elegans embryo as a model system, we identify a new CMG assembly factor called DNSN-1, which associates with the BRCT-domain protein MUS-101...
ORGANISM(S): Caenorhabditis elegans 
2023-10-24 | PXD044240 | Pride
Donson C. elegans Meier gorlin syndrome Mus-101 Dnsn-1 Cmg helicase Dna replication 
UnknownMolecular architecture of the human GINS complex.
Not available
S-EPMC1905900 | biostudies-literature
UnknownStructure of the Saccharolobus solfataricus GINS tetramer.
Not available
S-EPMC12035558 | biostudies-literature
UnknownArchitectures of archaeal GINS complexes, essential DNA replication initiation factors.
Not available
S-EPMC3114041 | biostudies-literature
UnknownGINS, a central nexus in the archaeal DNA replication fork.
Not available
S-EPMC1479547 | biostudies-literature
UnknownTopBP1 utilises a bipartite GINS binding mode to support genome replication.
Not available
S-EPMC10899662 | biostudies-literature
ProteomicsBipartite GINS binding mode of TopBP1 to activate the replicative helicase - Chromass Data Set
How the replicative Mcm2-7 helicase is activated during replication origin firing remains largely unknown. Our biochemical and structural studies reveal that the helicase activator GINS interacts with TopBP1 using two separate binding surfaces. One involves a stretch of highly conserved amino acids ...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2024-03-26 | PXD040024 | Pride
Xenopus egg extracts Dna replication 
UnknownComprehensive analysis of GINS subunits prognostic value and ceRNA network in sarcoma.
Not available
S-EPMC9462653 | biostudies-literature
UnknownTissue-Specific Requirement for the GINS Complex During Zebrafish Development.
Not available
S-EPMC7270345 | biostudies-literature
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