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ProteomicsDNSN-1 recruits GINS for CMG helicase assembly during DNA replication initiation in C. elegans
Assembly of the DNA helicase known as CMG (CDC45-MCM-GINS) is the key regulated step during DNA replication initiation in eukaryotes. Using the Caenorhabditis elegans embryo as a model system, we identify a new CMG assembly factor called DNSN-1, which associates with the BRCT-domain protein MUS-101...
ORGANISM(S): Caenorhabditis elegans 
2023-10-24 | PXD044240 | Pride
Donson C. elegans Meier gorlin syndrome Mus-101 Dnsn-1 Cmg helicase Dna replication 
UnknownRNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans.
Not available
S-EPMC5068962 | biostudies-literature
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Thymic Transcriptomes from Wild Type and Mir-146a Transgenic Mice
Purpose: To find out the global transcriptomic change induced by overexpression of miR-146a in thymus Methods:Thymic mRNA profile of two pools from age (five to six-week old)- and gender (one male and one female for each pool)- matched wild-type (WT) and miR-146a transgenic (Tg) mice were generated ...
ORGANISM(S): Mus musculus 
2018-02-14 | GSE99428 | GEO
GenomicsMus musculus strain:C57BL/6JRj
Mus musculus and Candida albicans Transcriptome in OPC
PRJNA491801 | ENA
TranscriptomicsTranscription profiling of mouse poloxamer P-407 chronic hyperlipidemia mouse model
We performed a systemic study of the poloxamer P-407-induced chronic hyperlipidemia in C57BL/6J mice. Mice were treated 96 days every third day.The poloxamer mostly elevates plasma triglycerides and cholesterol while change of the liver cholesterol is not significant. Experiment Overall Design: A g...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6305 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of mice with good and poor spatial learning during West Nile virus recovery
Greater than 50% of patients who survive neuroinvasive West Nile virus (WNV), a mosquito-borne, positive-sense strand flavivirus, exhibit cognitive sequelae including memory impairments which may last several years. High survival rates from WNV neuroinvasive disease (WNND) (>90%) have led to hundred...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-72139 | biostudies-arrayexpress
TranscriptomicsMouse cortical neuron transcriptional response to wild-type West Nile virus (WNV NY99 clone 382) and mutant virus WNV E218A [microRNA]
The purpose is to obtain samples for transcriptional analysis in triplicate wells using wild type West Nile virus (WNV NY99 clone 382; WNVWT) and mutant virus (WNVE218A) in mouse cortical neurons. This data set comprises two complete biological replicate experiments conducted in the same conditions ...
ORGANISM(S): Mus musculus 
2015-04-04 | E-GEOD-67474 | biostudies-arrayexpress
TranscriptomicsMouse cortical neuron transcriptional response to wild-type West Nile virus (WNV-NY) and mutant virus WNV E218A [mRNA]
The purpose is to obtain samples for transcriptional analysis in triplicate wells using wild type West Nile virus (WNV NY99 clone 382; WNVWT) and mutant virus (WNVE218A) in mouse cortical neurons. This data set comprises two complete biological replicate experiments conducted in the same conditions ...
ORGANISM(S): Mus musculus 
2015-04-04 | E-GEOD-67473 | biostudies-arrayexpress
UnknownThe influence of alcohol on genioglossus single motor units in men and women during wakefulness.
Not available
S-EPMC10103883 | biostudies-literature
GenomicsSynthetic reversed sequences reveal default genomic states
Pervasive transcriptional activity is observed across diverse species. The genomes of extant organisms have undergone billions of years of evolution, making it unclear whether these genomic activities represent effects of selection or ‘noise’1,2,3,4. Characterizing default genome states could help u...
ORGANISM(S): Saccharomyces cerevisiae Mus musculus 
2024-01-16 | GSE252482 | GEO
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