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ProteomicsHuman tRNA genes enable differential nonsense suppression in live cells and a model of frontotemporal dementia
Nonsense mutations generate premature termination codons (PTCs) that are responsible for 11% of human genetic disease alleles. Thus, nonsense suppressor tRNAs have broad therapeutic potential. Humans encode > 600 tRNA genes with many identical or similar copies of each tRNA. We hypothesized that tRN...
ORGANISM(S): Homo sapiens (Human) 
2025-07-25 | PXD056053 | Pride
Therapeutics Live-cell fluorescent reporters Frontotemporal dementia Trna Nonsense suppression Progranulin Protein synthesis 
UnknownCombining nonsense mutation suppression therapy with nonsense-mediated decay inhibition in neurofibromatosis type 1.
Not available
S-EPMC10384610 | biostudies-literature
GenomicsHigh-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs
High-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs
PRJNA1280181 | ENA
TranscriptomicsNonsense suppression as a mechanism of genetic complemtation in the opportunistic pathogen Mycobacterium marinum
Here, we report the discovery of a novel mechanism of genetic complementation in M. marinum. We found that nonsense suppression was causing genetic complementation. Nonsense suppression was linked to alterations in cell permeability and exposure to the aminoglycoside antibiotic, hygromycin.
ORGANISM(S): Mycobacterium marinum 
2019-06-08 | GSE83103 | GEO
UnknownNonsense suppression in archaea.
Not available
S-EPMC4434778 | biostudies-literature
GenomicsUse of NanoLuc-Based Reporters that Monitor Nonsense Suppression and Inhibition of Nonsense-Mediated mRNA Decay to Identify Potent New Agents That Partially Reverse the Effects of Nonsense Mutations
Use of NanoLuc-Based Reporters that Monitor Nonsense Suppression and Inhibition of Nonsense-Mediated mRNA Decay to Identify Potent New Agents That Partially Reverse the Effects of Nonsense Mutations
PRJNA602876 | ENA
UnknownNonsense mRNA suppression via nonstop decay.
Not available
S-EPMC5777819 | biostudies-literature
GenomicsA Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding
A Ψ–Ψ codon–anticodon pairing in nonsense suppression and translational recoding
PRJNA1273852 | ENA
ProteomicsEngineered transfer RNAs for suppression of premature termination codons
PTCs cause a multitude of human diseases and there are no established therapeutic options for their therapeutic management. Herein, we report the high-throughput cloning and identification, characterization and functional analysis of anticodon-edited tRNA which display efficacious PTC reversion in ...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2019-02-11 | PXD012581 | Pride
Anticodon edited trnas Ptc repair Ace-trnas 
TranscriptomicsHigh-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs
Nonsense mutations generate premature termination codons (PTCs) that are responsible for 11% of genetic disease alleles. The arginine (Arg, CGA) to stop (UGA) mutation is the most common PTC. Humans encode >600 tRNA genes with many identical and similar copies. We developed a dual fluorescent report...
ORGANISM(S): Homo sapiens 
2025-07-28 | GSE300389 | GEO
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