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TranscriptomicsInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progran...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
TranscriptomicsProgranulin A mediated MET signalling is essential for liver morphogenesis in zebrafish
Regulation of embryonic liver growth remains largely elusive. Progranulin has been discussed in pathological liver growth; however, the functional role of Pgrn in embryonic liver growth has never been addressed. Knockdown of GrnA, the orthologue of mammalian pgrn in zebrafish, displayed a deficien...
ORGANISM(S): Danio rerio 
2010-11-10 | E-GEOD-19211 | biostudies-arrayexpress
ProteomicsProtein expression in the prefrontal cortex of aged mice with progranulin deficiency or neuronal progranulin overexpression
Description: Progranulin deficiency is associated with neurodegeneration in humans and in mice. We performed a deep proteomic screen of the pre-frontal cortex in aged (13-15 months) female progranulin-deficient mice (GRN-/-) and mice with a neuron-specific inducible overexpression of progranulin (SL...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-13 | PXD004087 | Pride
Lc-ms/ms Mice Cortex Progranulin Neurodegeneration 
TranscriptomicsProgranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation
Microglia repair injury and maintain homeostasis in the brain, but whether aberrant microglial activation can contribute to neurodegeneration remains unclear. Here, we use transcriptome profiling to demonstrate that deficiency in frontotemporal dementia (FTD) gene progranulin (Grn) leads to an age-d...
ORGANISM(S): Mus musculus 
2016-03-31 | E-GEOD-75083 | biostudies-arrayexpress
GenomicsProgranulin promotes dendritic growth of hippocampal neurons by acting on astrocytes
Progranulin promotes dendritic growth of hippocampal neurons by acting on astrocytes
PRJNA1292268 | ENA
GenomicsProgranulin insufficiency and TDP-43 overexpression interact to worsen FTD-related phenotypes in mice.
Progranulin insufficiency and TDP-43 overexpression interact to worsen FTD-related phenotypes in mice.
PRJNA1306103 | ENA
GenomicsEffect of mouse and human progranulin haploinsufficiency on mouse cortical transcriptome at 18 months of age.
Effect of mouse and human progranulin haploinsufficiency on mouse cortical transcriptome at 18 months of age.
PRJNA847261 | ENA
TranscriptomicsProgranulin promotes dendritic growth of hippocampal neurons by acting on astrocytes
Progranulin is a secreted pro-protein that is trafficked to lysosomes and exerts protective effects in the brain. Progranulin (GRN) mutations, most of which cause progranulin haploinsufficiency, are a major genetic cause of frontotemporal dementia (FTD). Restoring progranulin to people with GRN muta...
ORGANISM(S): Rattus norvegicus 
2025-11-03 | GSE302849 | GEO
GenomicsAntisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation
Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation
PRJNA779079 | ENA
TranscriptomicsDisrupted processing of long pre-mRNAs and widespread RNA missplicing are components of neuronal vulnerability from loss of nuclear TDP-43 (RNA-seq)
Cross-linking and immunoprecipitation coupled with high-throughput sequencing was used to identify binding sites within 6,304 genes as the brain RNA targets for TDP-43, an RNA binding protein which when mutated causes Amyotrophic Lateral Sclerosis (ALS). Use of massively parallel sequencing and spli...
ORGANISM(S): Mus musculus 
2011-03-03 | E-GEOD-27218 | biostudies-arrayexpress
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