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TranscriptomicsCUT&RUN LoV-U of beta-catenin, TCF/LEF transcription factors and histone modifications in HEK293T and mouse embryonic hindlimb tissue at 11.5 days post coitum
In our attempts to profile different regulators of the WNT/b-catenin transcriptional complex, CUT&RUN failed to produce consistent binding patterns of the non-DNA-binding b-catenin. We developed a modified CUT&RUN protocol, which we refer to as LoV-U (Low Volume and Urea), that enables the generatio...
ORGANISM(S): Mus musculus 
2022-07-16 | E-MTAB-11951 | biostudies-arrayexpress
TranscriptomicsCUT&RUN experiment at four time points in HEK293T and hESC cells, assessing the time-resolved response of β-catenin genomic occupancy upon Wnt signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12077 | biostudies-arrayexpress
ProteomicsCUT&ID for 8 targets in HCT116 cells
Understanding how gene regulators bind DNA and interact with one another is essential for understanding gene expression, yet existing technologies typically measure either chromatin occupancy or protein–protein interactions in isolation, require high cell numbers, and/or depend on genetic engineerin...
ORGANISM(S): Homo sapiens (Human) 
2026-10-05 | PXD071610 | Pride
Cut&id 
TranscriptomicsCUT&RUN experiment in colon cancer cells (HCT116, DLD1 and SW620), assessing TBX3 genomic occupancy
The Wnt/β-catenin signaling pathway plays crucial roles in nearly all parts of embryonic development and adult stem cell homeostasis. Its aberrant activation has been linked to many diseases such as developmental irregularities and various severe forms of cancer, with colorectal cancer (CRC) as a pr...
ORGANISM(S): Homo sapiens 
2024-01-01 | E-MTAB-13646 | biostudies-arrayexpress
TranscriptomicsCUT&RUN of histone modifications, chromatin remodelers, and transcription factors in forelimbs, hindlimbs, liver and branchial arches of E10.5 and E11.5 JAX/Swiss mouse embryos
Using CUT&RUN, we systematically measured the genome-wide binding profiles of key transcription factors and cofactors that track the activity of ontogenetically relevant signaling pathways in developing mouse tissues. This produced numerous genome-wide biding tracks for different tissues at two deve...
ORGANISM(S): Mus musculus 
2024-08-12 | E-MTAB-14340 | biostudies-arrayexpress
UnknownHeterogeneous phenotype and cardiovascular comorbidities in Swedish patients with spinobulbar muscular atrophy.
Not available
S-EPMC12789218 | biostudies-literature
TranscriptomicsCUT&RUN of H3K4me1 in mESC
Profiling of H3K4me1 genome wide occupancy in mESC WT, LSD1 KO, and rescued with WT LSD1 (RO) and with mutant LSD1 (AK) to explore the effects of LSD1 on histone methylation.
ORGANISM(S): Mus musculus 
2024-08-12 | E-MTAB-14338 | biostudies-arrayexpress
TranscriptomicsCUT&ID of 8 targets in HCT116
We developed CUT&ID, that simultaneously profiles genome-wide DNA and protein associations of any endogenous target in its native state, from one sample in a single streamlined workflow, and with no need of cloning or transgenesis. CUT&ID is enabled by a single fusion protein combining TurboID, prot...
ORGANISM(S): Homo sapiens 
2025-12-28 | E-MTAB-16382 | biostudies-arrayexpress
TranscriptomicsRNA-seq experiment at four time points in HEK293 and hESC cells, assessing the time-resolved response on gene expression upon Wnt/β-catenin signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin-driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes human...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12075 | biostudies-arrayexpress
TranscriptomicsATAC-seq experiment at four time points in HEK293 and hESC cells, assessing the time-resolved response on chromatin accessibility upon Wnt/β-catenin signaling activation
Wnt/β-catenin signaling is a highly organized biochemical cascade that triggers a gene expression program in the signal-receiving cell. The Wnt/β-catenin -driven transcriptional response is involved in virtually all cellular processes during development, homeostasis, and its deregulation causes huma...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12076 | biostudies-arrayexpress
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