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ProteomicsIncorporation of nonproteinogenic amino acids into bacterial proteome analyzed by unbiased quantitative MS of protein modifications
To study incorporation of nonproteinogenic amino acids in bacterial proteome we performed a global, unbiased protein modification analysis of the E. coli K12 strain with defective editing mechanism of the leucyl tRNA synthetase (LeuRS), which in addition to leucine incorporates a nonproteinogenic am...
ORGANISM(S): Escherichia coli 
2016-07-11 | PXD003468 | Pride
Mistranslation Trna synthetase Norvaline Leucine Nonproteinogenic amino acids Orbitrap 
UnknownEfficacy of epetraborole against Mycobacterium abscessus is increased with norvaline.
Not available
S-EPMC8535176 | biostudies-literature
UnknownCrystal structure of the tripeptide N-(benzyl-oxycarbon-yl)glycylglycyl-l-norvaline.
Not available
S-EPMC4350747 | biostudies-literature
UnknownThe physiological target for LeuRS translational quality control is norvaline.
Not available
S-EPMC4194098 | biostudies-literature
UnknownLeucyl-tRNA Synthetase Inhibitor, D-Norvaline, in Combination with Oxacillin, Is Effective against Methicillin-Resistant Staphylococcus aureus.
Not available
S-EPMC9137938 | biostudies-literature
ProteomicsOn the mechanism and origin of isoleucyl-tRNA synthetase editing against norvaline
Aminoacyl-tRNA synthetases (aaRSs), the enzymes responsible for coupling tRNAs to their cognate amino acids, minimize translational errors by intrinsic hydrolytic editing. Here, we compared the propensity of norvaline (Nva), a linear amino acid not coded for protein synthesis, to the proteinogenic, ...
ORGANISM(S): Escherichia coli 
2019-01-28 | PXD011051 | Pride
Isoleucyl-trna synthetase E. coli Mistranslation 
TranscriptomicsLactococcus lactis stringent response
The stringent response was defined in Lactococcus lactis through transcript profiling after the addition of a chemical inductor, the norvaline. Gene expression was measured in the exponential growth phase (reference sample) and at 1.6 h after norvaline addition. Four hundred and sixty one differenti...
ORGANISM(S): Lactococcus lactis 
2010-06-25 | E-GEOD-10254 | biostudies-arrayexpress
UnknownSelf-protective responses to norvaline-induced stress in a leucyl-tRNA synthetase editing-deficient yeast strain.
Not available
S-EPMC5499588 | biostudies-literature
TranscriptomicsLactococcus lactis stringent response
The stringent response was defined in Lactococcus lactis through transcript profiling after the addition of a chemical inductor, the norvaline. Gene expression was measured in the exponential growth phase (reference sample) and at 1.6 h after norvaline addition. Four hundred and sixty one differenti...
ORGANISM(S): Lactococcus lactis 
2009-04-28 | GSE10254 | GEO
ProteomicsResiliance and proteome response of Escherichia coli to high levels of isoleucine mistranslation
Correct pairing of amino acids and tRNA is prerequisite for correct translation of genetic information during protein biosynthesis. Here, we present effects of proteome-wide isoleucine mistranslation in Escherichia coli induced by editing-defective isoleucyl-tRNA synthetase (IleRS). Two types of mis...
ORGANISM(S): Escherichia Coli 
2024-02-26 | PXD041341 | JPOST Repository
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