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TranscriptomicsNotch regulated miRNAs in human T-ALL cell line
In an attempt to identify miRNAs regulated by oncogenic Notch signaling, we performed miRNA profiling of human T-cell acute lymphoblastic leukemia (T-ALL) cells with or without the treatment of γ-secretase inhibitor (GSI) to block Notch signaling. We found miR-223 levels to increase after GSI treatm...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-35993 | biostudies-arrayexpress
TranscriptomicsGenome wide profiling of Su(H) [CSL] binding in Drosophila melanogaster larval CNSs where Notch is hyperactive in neuroblasts for 24 hours
The Notch pathway is a well conserved cell to cell communication mechanism that is normally involved in many developmental processes and when aberrantly activated it leads to diseases such as cancer. One such example is the neural stem cell tumours that arise from constitutive Notch activity in Dros...
ORGANISM(S): Drosophila melanogaster 
2015-12-15 | E-GEOD-68614 | biostudies-arrayexpress
TranscriptomicsHypoxia-induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling
Hypoxia (low oxygen) and Notch signaling are two important regulators of vascular development, but how they interact in controlling the choice between arterial and venous fates for endothelial cells during vasculogenesis is less well understood. In this report, we show that hypoxia and Notch signali...
ORGANISM(S): Mus musculus 
2013-02-08 | E-GEOD-35894 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MOLT4 cell lines before and after inhibition of gamma secretase to investigate NOTCH signaling in T-cell acute lymphoblastic leukemia cell lines
In T-cell acute lymphoblastic leukemia (T-ALL) NOTCH 1 receptors are frequently mutated. This leads to aberrantly high Notch signaling, but how this translates into deregulated cell cycle control and the transformed cell type is poorly understood. In this report, we analyze downstream responses resu...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6495 | biostudies-arrayexpress
TranscriptomicsHuman T-ALL cell line response to inhibition of Notch signaling
Analysis of five Notch signaling-dependent human T-ALL cell lines (ALLSIL, DND41, HPBALL, KOPTK1, TALL-1) treated with gamma-secretase inhibitor (GSI) to block Notch signaling. Samples include parental cells, cells rescued by retroviral transduction with ICN (a GSI-independent form of activated Notc...
ORGANISM(S): Homo sapiens 
2011-07-31 | E-GEOD-29959 | biostudies-arrayexpress
TranscriptomicsChromatin signatures at Notch regulated enhancers reveal large-scale changes in H3K56ac upon activation
To investigate the influence of chromatin organization and dynamics on the response to Notch signaling, we partitioned Drosophila chromatin using histone modifications and established This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66227 | biostudies-arrayexpress
TranscriptomicsCell-context dependent Notch target genes
Notch signaling regulates a variety of developmental cell fates decisions in a cell-context dependent manner. Although Notch signaling directly regulates transcription via the RBP-J/CSL DNA binding protein, little is known about the genes in the respective tissues that are directly activated by Notc...
ORGANISM(S): Mus musculus 
2010-07-13 | E-GEOD-15268 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of Endometrial organoids treated with NOTCH or WNT inhibitors in a time course of Estrogen and Progesterone stimulation
We performed single-cell RNA-sequencing of 3D endometrial organoid cultures in order to dissect the signaling pathways that determine cell fate of epithelial lineages. Every time course was obtained in a background that either included or did not include ovarian hormones stimulation, which emulates ...
ORGANISM(S): Homo sapiens 
2021-07-21 | E-MTAB-10283 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of H3K56ac in Drosophila melanogaster Kc167 cell lines with NICD overexpression
The conserved Notch pathway functions in diverse developmental and disease-related processes, requiring mechanisms to ensure appropriate target-selection and gene activation in each context. To investigate, we partitioned Drosophila chromatin into different states, based on histone modifications, es...
ORGANISM(S): Drosophila melanogaster 
2015-07-01 | E-GEOD-66221 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of Adult and Fetal Enteroids (Control or Treated with DBZ)
Bulk RNA sequencing data of both adult and fetal enteroid lines cultured for 1 or 3 days. Conditions include enteroids grown in control basal media and basal media with the notch inhibitor DBZ added.
ORGANISM(S): Homo sapiens 
2022-04-08 | E-MTAB-11619 | biostudies-arrayexpress
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