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TranscriptomicsTP53 and TP63 modulation of Squamous PDAC
Based on the association of TP53 mutation and upregulated TP63 expression in the squamous subtype, we used cell lines derived from genetically engineered mouse models of PDAC (KRAS Trp53fl/+ and KRAS Trp53fl/+ Trp63fl/fl) to begin to unravel the functional consequences of these events in defining sq...
ORGANISM(S): Mus musculus 
2016-03-03 | E-MTAB-4415 | biostudies-arrayexpress
UnknownEnhanced metastasis risk prediction in cutaneous squamous cell carcinoma using deep learning and computational histopathology.
Not available
S-EPMC12405460 | biostudies-literature
TranscriptomicsGenome-wide DNA methylation patterns in pancreatic ductal adenocarcinoma (PDAC)
Determine methylation pattern in PDAC a genome-wide analysis was performed in a cohort of 167 PDAC and 29 adjacent pancreatic tissues samples using the Infinium 450k methylation arrays (Illumina). 167 pancreatic tumors (PDAC) x 29 adjacent -non tumor samples.
ORGANISM(S): Homo sapiens 
2014-07-08 | E-GEOD-49149 | biostudies-arrayexpress
GenomicsGenomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Oesophageal adenocarcinoma (EAC) incidence is rapidly increasing in Western countries. A better understanding of EAC underpins efforts to improve early detection and treatment outcomes. While large EAC exome sequencing efforts to date have found recurrent loss-of-function mutations, oncogenic drivin...
EGAS00001000750 | EGA
ProteomicsMetabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-07-18 | MSV000092468 | MassIVE
GenomicsQCMG_20140410_OESO - samples
Description not provided
EGAD00001000845 | EGA
GenomicsWhole Genome Sequencing of Esophageal Adenocarcinomas DAC
Data Access Committee EGAC00001000192
EGAC00001000192 | EGA
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
MetabolomicsGNPS - Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target
The genomic landscape of colorectal cancer (CRC) is shaped by inactivating mutations in tumour suppressors such as APC, and oncogenic mutations such as mutant KRAS. Here we used genetically engineered mouse models (GEMMs), and multimodal mass spectrometry-based metabolomics to study the impact of co...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2023-07-18 | MSV000092468 | GNPS
GenomicsRNASeq_PACA-AU_Apr_2017 - samples
BAM outputs from RSEM (https://deweylab.github.io/RSEM/) analysis of RNASeq sequencing on HiSeq platform of tumour samples from 95 pancreatic adenocarcinoma cases.
EGAD00001003298 | EGA
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