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hnRNPA is a novel regulator of a mitochondrial microprotein expression
Microproteins encoded by short open reading frames (sORFs) of less than 100 codons have been predicted to constitute a substantial fraction of the eukaryotic proteome. However, relevance and roles of the majority of microproteins remain undefined because only a small fraction of these intriguing cel...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD057806 | Pride
Microproteins encoded by short open reading frames (sORFs) of less than 100 codons have been predicted to constitute a substantial fraction of the eukaryotic proteome. However, relevance and roles of the majority of microproteins remain undefined because only a small fraction of these intriguing cel...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD058567 | Pride
Mitochondrial-derived peptides (MDPs) are microproteins that are encoded by short open reading frames within the mitochondrial genome. Several MDPs have been identified in recent years; however, the transcriptional and translational regulation of MDPs remain poorly understood. Here we discovered an ...
ORGANISM(S): Homo sapiens 
2024-12-08 | GSE169283 | GEO
A Novel Microprotein, MUCP1, Mediates Succinate Transport and Promotes Colorectal Cancer Progression by Modulating Glutamine Metabolism
These findings establish minion as a novel microprotein required for muscle development, and define a two-component program for the induction of mammalian cell fusion.
ORGANISM(S): Mus musculus 
2017-05-19 | GSE97764 | GEO
Metabolic dysfunction-associated steatotic liver disease (MASLD) represents a major global health challenge with limited therapeutic options. To identify new regulators of lipid metabolism, we developed a novel proteomic strategy combining organelle enrichment with a custom sORF database to explore ...
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD073193 | Pride
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