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MetabolomicsMetabolomic analysis of the mechanism of action of yerba mate extract on Salmonella Typhimurium
Background: Salmonella Typhimurium is a gram-negative enteropathogen that infects millions worldwide; the rapid emergence of antibiotic resistant strains has heightened the urgency of developing effective treatment for this pathogen. Previous studies have demonstrated that the aqueous extract of yer...
2017-02-16 | MTBLS359 | MetaboLights
MetabolomicsCell Atlas and Novel Signal Processing Strategy in Primate Insular Cortex

The anterior insular cortex (AIC) is a critical hub integrating exteroceptive and interoceptive information into high-order cognition, yet its neural basis remains incompletely understood. Here, by combining whole-cell-based single-cell transcriptomics with Patch-seq recordings, we resolved and c...

2026-02-28 | MTBLS13927 | MetaboLights
ProteomicsMManassantin A iTRAQ-SPROX Drug Mode-of-Action
Manassantin A is a natural product that has been isolated from the perennial herb Saururus chinensis Baill and the aquatic plant Saururus cernuus. Manassantin A has been shown to possess potent hypoxia inducible factor 1 alpha (HIF-1α) inhibitory activity in a cell-based assay screen of thousands o...
ORGANISM(S): Homo sapiens (Human) 
2016-07-12 | PXD002304 | Pride
Drug mode-of-action Stability of proteins from rates of oxidation (sprox) Mda-mb-231 Protein-ligand binding interactions Manassantin a Itraq 
TranscriptomicsExpression data in whole Arabidopsis seedlings after treatment with the herbicide dicamba
Dicamba is an auxin-like herbicide that can stimulate the production of ethylene and ABA biosynthesis. The subsequent stomatal closure and build-up of reactive oxygen species is hypothesized to contribute to plant death. In order to further understand the herbicide dicamba's mode of action at the m...
ORGANISM(S): Arabidopsis thaliana 
2010-12-10 | E-GEOD-24052 | biostudies-arrayexpress
MetabolomicsSmall Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
2021-11-04 | MTBLS788 | MetaboLights
ProteomicsSynthesis, Insecticidal Activities and Mode of Action of Novel Imidazopyridine Mesoionic Derivatives Containing an Amido group
KEGG enrichment analysis showed that the proteins which differentially expressed between the control and C6-treated groups are mainly enriched in pathways of neurodegeneration (ko05022), amyotrophic lateral sclerosis (ko05014), prion disease (ko05020), parkinson disease (ko05012) and huntington dise...
ORGANISM(S): Aphis Craccivora 
2022-06-27 | PXD034928 |
GenomicsMode of action characterization of antibiotics using expression profile fingerprints generated by RNA-sequencing technology
Mode of action characterization of antibiotics using expression profile fingerprints generated by RNA-sequencing technology
PRJNA432937 | ENA
TranscriptomicsMode of action studies of the novel bisquaternary bisnaphthalimide MT02 against Staphylococcus aureus
Screening of various bisquaternary bisnaphthalimides against a variety of human pathogens revealed one compound, designated MT02, with strong inhibitory effects against gram-positive bacteria. The minimal inhibitory concentrations ranged from 0.31 µg/ml against community-acquired methicillin resista...
ORGANISM(S): Staphylococcus aureus 
2011-01-04 | E-GEOD-23077 | biostudies-arrayexpress
ProteomicsFirst-in-class DUB Molecular Glues and Inhibitors of Inflammation
Deubiquitylases (DUBs) play a pivotal role in cell signalling and are often regulated by homo- or hetero-interactions within protein complexes. The BRCC36 isopeptidase complex (BRISC) regulates inflammatory signalling by selectively cleaving K63-linked polyubiquitin chains on Type I interferon recep...
ORGANISM(S): Homo sapiens (Human) 
2025-02-06 | PXD044584 | Pride
Inhibitor Molecular glues Hydrogen deuterium exchange Hdx Deubiquitylase 
MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
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