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ProteomicsPre-histopathological and sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: a multi-omic analysis
Like many neurological disorders, Alzheimer’s disease has a sex-biased epidemiological profile, affecting approximately twice as many women as men. The cause of this sex difference has yet to be elucidated. To identify molecular correlates of this sex bias, we investigated molecular pathology in f...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-10 | PXD006587 | Pride
Alzheimer's disease Hippocampus Proteomics Sex differences Lc-ms/ms 
TranscriptomicsTranscriptomic Analysis of the Hippocampus from Six Inbred Strains of Mice Suggests Basis for Sex-Specific Susceptibility and Severity of Neurological Disorders
Identifying sex differences in gene expression within the brain is critical for determining why multiple neurological and behavioural disorders differentially affect males and females. Several are more common or severe in males (e.g., autism and schizophrenia) or females (e.g., Alzheimer’s disease...
ORGANISM(S): Mus musculus 
2016-01-06 | E-GEOD-76567 | biostudies-arrayexpress
ProteomicsMouse_Hippocampus_LCMSMS_IEF_Pooling
Protein extract from a single mouse hippocampus was enzymatically digested and fractionated by isoelectric focusing. Aliquots of fractions were pooled to make fewer, more complex samples. The unfractionated lysate, fractions, and pooled fractions were subjected to liquid chromatography–mass spectrom...
ORGANISM(S): Mus musculus (Mouse) 
2016-05-09 | PXD002905 | Pride
Brain Hippocampus Isoelectric focusing Mouse Lc-msms 
ProteomicsMouse_Hippocampus_LCMSMS_IEF_Pooling
Protein extract from a single mouse hippocampus was enzymatically digested and fractionated by isoelectric focusing. Aliquots of fractions were pooled to make fewer, more complex samples. The unfractionated lysate, fractions, and pooled fractions were subjected to liquid chromatographyâ??mass spectr...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-02-21 | MSV000084999 | MassIVE
ProteomicsSex differences in the molecular signature of the developing mouse hippocampus
We used LC-MS/MS based proteomics to identify changes in protein expression in the the female and male mouse hippocampus at 1, 2, and 4 months of age. This proteomics dataset was correlated with an accompanying mRNA dataset to identify genes that show mRNA changes in a different direction that their...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-21 | PXD004496 | Pride
Hippocampus Development Mouse Lc-ms/ms 
UnknownMolecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Not available
S-EPMC6369924 | biostudies-literature
TranscriptomicsGenetics of the hippocampal transcriptome in mouse: a systematic survey and online neurogenomics resource
The Hippocampus Consortium data set provides estimates of mRNA expression in the adult hippocampus of 99 genetically diverse strains of mice including 67 BXD recombinant inbred strains, 13 CXB recombinant inbred strains, a diverse set of common inbred strains, and two reciprocal F1 hybrids. The hipp...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-84767 | biostudies-arrayexpress
TranscriptomicsA comprehensive examination of dynamic gene expression changes in the mouse brain during pregnancy and the postpartum period
The developmental transition to motherhood requires gene expression changes that alter the brain to prepare and drive the female to perform maternal behaviors. Furthermore, it is expected that the many physiological changes accompanying pregnancy and postpartum stages will impact brain gene expressi...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-70732 | biostudies-arrayexpress
UnknownCharacterizing Long COVID Symptoms During Early Childhood.
Not available
S-EPMC12117493 | biostudies-literature
UnknownEthnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from the RECOVER Initiative.
Not available
S-EPMC11753962 | biostudies-literature
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