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ProteomicsActinomycin targets NPM1c-primed mitochondria in AML
Acute myeloid leukemia (AML) pathogenesis often involves a mutation in the NPM1 nucleolar chaperone, but the bases for its transforming properties and association with favorable outcome remain incompletely understood. Here we demonstrate that an oncogenic mutant form of NPM1 (NPM1c) hampers formatio...
ORGANISM(S): Homo sapiens (Human) 
2021-12-17 | PXD025507 | Pride
Pml Lfq Actinomycin d Mitochondria Npm1c Qexactive Senescence 
GenomicsDriver mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in Acute Myeloid Leukemia
Recent evidence suggests that inhibition of BET epigenetic readers may have clinical utility in hematological malignancies. We demonstrate the efficacy of the BET inhibitor I-BET151 across a variety of AML subtypes, and demonstrate that a common core transcriptional program, which is HOX gene-indepe...
ORGANISM(S): Homo sapiens 
2014-12-12 | E-MTAB-1443 | biostudies-arrayexpress
GenomicsChromation accessibility profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD
Chromation accessibility profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD
PRJNA889925 | ENA
GenomicsGene expression profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD
Gene expression profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD
PRJNA889926 | ENA
GenomicsDNA methylation profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD
DNA methylation profiles of cKit positive bone marrow cells from six genotype mice - WT, Idh1R132, Npm1c, Flt3ITD, Idh1R132+Npm1c, and Idh1R132+Flt3ITD
PRJNA889927 | ENA
GenomicsNPM1c hijacks the active trancription in leukemia development [CUT&RUN]
NPM1c hijacks the active trancription in leukemia development [CUT&RUN]
PRJNA810062 | ENA
GenomicsNPM1c hijacks the active trancription in leukemia development [BRU-Seq]
NPM1c hijacks the active trancription in leukemia development [BRU-Seq]
PRJNA810038 | ENA
GenomicsNPM1c hijacks the active trancription in leukemia development [ATAC-Seq]
NPM1c hijacks the active trancription in leukemia development [ATAC-Seq]
PRJNA810037 | ENA
GenomicsNPM1c hijacks the active trancription in leukemia development [RNA-Seq]
NPM1c hijacks the active trancription in leukemia development [RNA-Seq]
PRJNA810046 | ENA
GenomicsNPM1c hijacks the active trancription in leukemia development [ChIP-Seq]
NPM1c hijacks the active trancription in leukemia development [ChIP-Seq]
PRJNA810061 | ENA
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