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ProteomicsTargeting the paralog encoded protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition
The activation of Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons not only leads to genome instability, a factor associated with the development of human diseases, but also plays crucial biological roles in fostering genetic diversity and neuronal functions. Therefore, investigating ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-07 | PXD051452 | Pride
Line1 Retrotransposon Nrbp2 Nrbp1 
ProteomicsThe pseudokinase NRBP1 activates Rac/Cdc42 via P-Rex1 to drive oncogenic signalling in triple negative breast cancer
In an effort to identify oncogenic protein kinase drivers in triple negative breast cancer (TNBC), we undertook mass spectrometry (MS)-based proteomic profiling across a large panel of TNBC cell lines. This revealed marked variation in expression of the multidomain pseudokinase Nuclear Receptor Bind...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD032168 | Pride
G proteins Proteomics Signal transduction Scaffold proteins 
ProteomicsMudit analyses of the proteins substrates candidate of NRBP1 using TR-TUBE system
293 stable cell line expressing NRBP1 or NRBP1 mutant were transfected with HA-TR-TUBE using TR-TUBE system to protect the degradation of the ubiquitin chains of the potential ligase substrate. The complexes were pulled down using anti-HA antibody and subsequently digested with modified Trypsin. Ant...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-10-04 | MSV000084419 | MassIVE
UnknownNRBP1 pseudokinase binds to and activates the WNK pathway in response to osmotic stress.
Not available
S-EPMC12266122 | biostudies-literature
UnknownNRBP1 and TSC22D proteins affect distal convoluted tubule physiology through modulation of the WNK pathway.
Not available
S-EPMC12266109 | biostudies-literature
UnknownNRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway.
Not available
S-EPMC11702584 | biostudies-literature
UnknownThe pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer.
Not available
S-EPMC10005955 | biostudies-literature
UnknownTRIM24 promotes proliferation and metastasis of gastric cancer via mediating NRBP1 ubiquitination.
Not available
S-EPMC12749008 | biostudies-literature
UnknownMicroglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine.
Not available
S-EPMC9095473 | biostudies-literature
UnknownCircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1.
Not available
S-EPMC8220703 | biostudies-literature
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