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ProteomicsTargeting the paralog encoded protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition
The activation of Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons not only leads to genome instability, a factor associated with the development of human diseases, but also plays crucial biological roles in fostering genetic diversity and neuronal functions. Therefore, investigating ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-07 | PXD051452 | Pride
Line1 Retrotransposon Nrbp2 Nrbp1 
UnknownNRBP2 Functions as a Tumor Suppressor and Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer.
Not available
S-EPMC8012753 | biostudies-literature
GenomicsKLF4/MLL3 axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells
KLF4/MLL3 axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells
PRJNA1312010 | ENA
GenomicsKLF4/MLL3 Complex axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells
KLF4/MLL3 Complex axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells
PRJNA1454387 | ENA
GenomicsKLF4/MLL3 Complex axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells [Cut & Tag]
KLF4/MLL3 Complex axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells [Cut & Tag]
PRJNA1453810 | ENA
TranscriptomicsKLF4/MLL3 axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells
Acute myeloid leukemia (AML) is a heterogeneous malignancy rooted in hematopoietic stem cell dysregulation. Despite therapeutic advances, clinical outcomes remain unsatisfactory. Here, we identify KLF4, a zinc-finger (ZnF) transcription factor with previously reported context-dependent roles in hema...
ORGANISM(S): Homo sapiens 
2026-08-15 | GSE306746 | GEO
GenomicsKLF4/MLL3 Complex axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells
Acute myeloid leukemia (AML) is a heterogeneous malignancy rooted in hematopoietic stem cell dysregulation. Despite therapeutic advances, clinical outcomes remain unsatisfactory. Here, we identify KLF4, a zinc-finger (ZnF) transcription factor with previously reported context-dependent roles in hema...
ORGANISM(S): Homo sapiens 
2026-08-15 | GSE328227 | GEO
GenomicsKLF4/MLL3 Complex axis Drives NRBP2 Transcription to Eliminate Acute Myeloid Leukemia Cells [Cut & Tag]
Acute myeloid leukemia (AML) is a heterogeneous malignancy rooted in hematopoietic stem cell dysregulation. Despite therapeutic advances, clinical outcomes remain unsatisfactory. Here, we identify KLF4, a zinc-finger (ZnF) transcription factor with previously reported context-dependent roles in hema...
ORGANISM(S): Homo sapiens 
2026-08-15 | GSE328080 | GEO
UnknownThe altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy.
Not available
S-EPMC6476534 | biostudies-literature
UnknownGATA binding protein 1 recruits histone deacetylase 2 to the promoter region of nuclear receptor binding protein 2 to affect the tumor microenvironment and malignancy of thyroid carcinoma.
Not available
S-EPMC9278442 | biostudies-literature
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